Chagas Disease Prevalence in Colombia: A Meta-Analysis and Systematic Review

Vector Borne and Zoonotic Diseases
Anthoni F LlauNasar U Ahmed

Abstract

Chagas disease is a major public health problem in Latin America. A neglected disease of poor and rural Latin American populations, it has now emerged in other regions and urban areas due to international migration. In Colombia, systematic data pertaining to the disease's magnitude in the general population and its distribution within regions are lacking. Our objective is to describe the prevalence of Chagas disease in Colombia through a meta-analysis and systematic review. A comprehensive search using several electronic databases, gray literature, and reference lists of selected articles for population-based studies on Chagas disease prevalence in Colombia was performed between 1990 and 2017. Articles published in either English or Spanish were included. Pooled prevalence estimates and 95% confidence intervals (CIs) were calculated for Chagas disease in the general population using a meta-analysis random-effects model. Subgroup analyses were performed to investigate potential sources of heterogeneity among studies. A sensitivity analysis was conducted to determine whether publication bias existed. Seventeen articles with relevant prevalence data were identified from a total of 1213 references. The initial pooled estimate of Ch...Continue Reading

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