Chain reactions: molecular mechanisms of RBR ubiquitin ligases.

Biochemical Society Transactions
Thomas R Cotton, Bernhard C Lechtenberg

Abstract

Ubiquitination is a fundamental post-translational modification that regulates almost all aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases. The RING-between-RING (RBR) family of E3 ligases encompasses 14 distinct human enzymes that are defined by a unique domain organisation and catalytic mechanism. Detailed characterisation of several RBR ligase family members in the last decade has revealed common structural and mechanistic features. At the same time these studies have highlighted critical differences with respect to autoinhibition, activation and catalysis. Importantly, the majority of RBR E3 ligases remain poorly studied, and thus the extent of diversity within the family remains unknown. In this mini-review we outline the current understanding of the RBR E3 mechanism, structure and regulation with a particular focus on recent findings and developments that will shape the field in coming years.

References

Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Jun 6, 2003·Cell·Gali PragJames H Hurley
Apr 27, 2004·Nature Immunology·Tsung-Hsien Chuang, Richard J Ulevitch
May 21, 2004·Physiological Genomics·Ignacio MarínAlberto Ferrús
Feb 22, 2005·Methods : a Companion to Methods in Enzymology·Donald S KirkpatrickSteven P Gygi
Jul 5, 2005·Science·Ken Cadwell, Laurent Coscoy
Sep 14, 2006·The Journal of Biological Chemistry·Colleen FearnsTsung-Hsien Chuang
Sep 29, 2006·The EMBO Journal·Takayoshi KirisakoKazuhiro Iwai
Oct 13, 2006·The Biochemical Journal·James H HurleyGali Prag
Dec 22, 2010·Molecular Cell·Yuichiro ShimizuLinda M Hendershot
Jun 23, 2011·The EMBO Journal·Viduth K ChauguleHelen Walden
Sep 3, 2011·Traffic·Xiaoli WangTed H Hansen
Apr 25, 2012·Annual Review of Biochemistry·David Komander, Michael Rape
Jul 14, 2012·EMBO Reports·Benjamin StieglitzKatrin Rittinger
May 10, 2013·The New England Journal of Medicine·David H MargolinStephanie B Seminara
May 11, 2013·Science·Jean-François TrempeKalle Gehring
Jun 4, 2013·The EMBO Journal·Tobias Wauer, David Komander
Oct 22, 2013·Nature·Benjamin StieglitzKatrin Rittinger
Mar 1, 2014·The Biochemical Journal·Donald E SprattGary S Shaw
Apr 5, 2014·Nature Structural & Molecular Biology·Christopher E Berndsen, Cynthia Wolberger
Jun 20, 2014·Neuron·Angela M MabbMichael D Ehlers
Jan 23, 2015·Neuron·Alicia M Pickrell, Richard J Youle
Jul 15, 2015·Nature·Tobias WauerDavid Komander
Jul 29, 2015·The Journal of Biological Chemistry·Shiuh-Rong HoWeei-Chin Lin
Jan 21, 2016·Nature·Bernhard C LechtenbergStefan J Riedl
Mar 24, 2016·Cell Research·Mikaela D StewartPeter S Brzovic
Mar 26, 2016·Cell Research·Kirby N Swatek, David Komander
Jun 18, 2016·EMBO Reports·Katja K DoveRachel E Klevit
Apr 18, 2017·Nature Structural & Molecular Biology·Atul KumarHelen Walden
Apr 28, 2017·Open Biology·Katrin Rittinger, Fumiyo Ikeda
Aug 23, 2017·Journal of Molecular Biology·Katja K Dove, Rachel E Klevit
Sep 26, 2017·Molecular Cell·Martin A MichelDavid Komander
Dec 8, 2017·The EMBO Journal·Elena PurlyteDario R Alessi

❮ Previous
Next ❯

Citations

Nov 13, 2020·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Fumiyo Ikeda
Jan 9, 2021·Cell Death and Differentiation·Marlene F SchmidtGrant Dewson
Dec 4, 2020·Current Opinion in Structural Biology·Sarath Ramachandran, Alessio Ciulli
Feb 14, 2021·Molecular and Cellular Neurosciences·Hiroshi Kawabe, Judith Stegmüller
Apr 8, 2021·Cellular and Molecular Life Sciences : CMLS·Olga Sokolova, Michael Naumann
Sep 14, 2021·EMBO Reports·Ishita Tripathi-GiesgenArno F Alpi
Oct 29, 2021·Biochemical Society Transactions·Andrew AboujaoudeSharmistha Mitra

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
ubiquitination
NMR

Software Mentioned

MS
AQUA
HDX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.