Chain termination codons and polymerase-induced frameshift mutations

FEBS Letters
J L Jestin, A Kempf

Abstract

The consensus sequence for single-base deletions in non-reiterated runs during in vitro DNA-dependent DNA polymerisation is refined using data available in the literature. This leads to the observation that chain termination codons are hotspots for single-base deletions. The evolutionary implications are discussed in two models which differ in whether polymerases evolved while the genetic code emerged or after the genetic code was fixed. A possible answer to the question 'Why are stop codons just what they are?' is suggested.

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Citations

Oct 21, 2009·Journal of Molecular Evolution·J L Jestin, A Kempf
Jun 8, 2007·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Alexander Gutfraind, Achim Kempf
Sep 18, 2013·Bio Systems·Hervé Seligmann, Antonieta Labra
Jun 19, 2002·Bio Systems·Liaofu Luo, Xiaoqin Li
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Mar 12, 2010·Journal of Theoretical Biology·José Santos, Angel Monteagudo
Aug 21, 2007·Journal of Theoretical Biology·Hervé Seligmann
Apr 24, 2007·Journal of Theoretical Biology·Jean-Luc Jestin, Christophe Soulé
Sep 24, 2004·Journal of Biotechnology·Jean-Luc Jestin, Pierre Alexandre Kaminski
Mar 21, 2006·Comptes rendus biologies·Jean-Luc Jestin
Apr 12, 2017·Frontiers in Genetics·Nawal El Houmami, Hervé Seligmann

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