Chalcone Derivatives 4'-Amino-1-Naphthyl-Chalcone (D14) and 4'-Amino-4-Methyl-1-Naphthyl-Chalcone (D15) Suppress Migration and Invasion of Osteosarcoma Cells Mediated by p53 Regulating EMT-Related Genes

International Journal of Molecular Sciences
Viviane SebaMozart Marins

Abstract

Osteosarcoma (OS) is a primary malignant bone tumor that mainly affects children, adolescents, and young adults. The inhibition of metastasis is a main strategy of OS therapy since the development of metastatic disease due to drug resistance remains the most important cause of death from this cancer. Considering the severe side effects of current OS chemotherapy, the identification of anti-metastatic drugs with reduced toxicity is of great interest. Chalcones are polyphenols with a basic structure consisting of an α-, β-unsaturated carbonyl system linking two aryl rings. These compounds exhibit anticancer activity against a variety of tumor cell lines through multiple mechanisms, including the regulation of the tumor-suppressor protein p53 and its target genes. An important process regulated by p53 is epithelial-mesenchymal transition (EMT), which facilitates tumor metastasis by conferring migratory and invasive properties to cancer cells. The activation of p53 can revert EMT and reduce migration and invasion. This study aimed to examine the inhibitory effects of two 4'-aminochalcones on the migration/invasion of the U2OS (p53+/+) and SAOS-2 (p53-/-) OS cell lines as well as the underlying molecular mechanisms. Cell viability w...Continue Reading

References

Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·G LiuG Lozano
Apr 14, 2005·Molecular Cancer Therapeutics·Minoru NakaseToshiro Tagawa
Aug 9, 2005·The Journal of Surgical Research·Kristin BjørnlandGunhild M Maelandsmo
Dec 1, 2007·Journal of Biochemistry and Molecular Biology·Hyun-Ji ChoYoung-Chae Chang
Dec 25, 2008·Neoplasia : an International Journal for Oncology Research·Sun-Hye LeeBum-Joon Park
Nov 13, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Phuong T NguyenTakashi Takata
Jan 6, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Amir-Shaya ShariliImelda McGonnell
Apr 27, 2011·The Journal of Experimental Medicine·Taewan KimCarlo M Croce
Jun 21, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Monique M NijkampJohan Bussink
Oct 26, 2011·The Journal of Cell Biology·Nam Hee KimJong In Yook
Apr 16, 2013·Biochemical and Biophysical Research Communications·Jianchao ZhangJun Lu
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jie JinXue-Song Zhou
Aug 6, 2013·Molecular Cancer Research : MCR·Yu-Chen LeeSue-Hwa Lin
Aug 27, 2013·Medical Oncology·Guoqiong YangKanghua Li
Sep 18, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L WangS Hu
Dec 20, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriel SilvaMozart Marins
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck
Mar 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui LiTao Xiao
Mar 25, 2014·Cancer Discovery·Emily PowellHelen Piwnica-Worms
Sep 2, 2014·International Journal of Oncology·Andrew WalkerKathryn R Lawson
Oct 17, 2014·Nature Reviews. Cancer·Maya KansaraDavid M Thomas
Dec 17, 2014·Neoplasia : an International Journal for Oncology Research·Giovanna Ferrari-AmorottiBruno Calabretta
May 26, 2015·European Journal of Medicinal Chemistry·Debarshi Kar MahapatraVivek Asati
Aug 22, 2015·Molecular Carcinogenesis·Gabriel SilvaSeung Joon Baek
Nov 29, 2015·The Orthopedic Clinics of North America·Megan E Anderson
Mar 26, 2016·Journal of Experimental & Clinical Cancer Research : CR·Chenghe WangZhangqun Ye
Dec 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Luis Felipe Buso BortolottoAna Lúcia Fachin
Jul 25, 2017·European Journal of Medicinal Chemistry·Mariana B SantosLuis O Regasini
Oct 21, 2017·Genes & Development·Daniel D Liu, Yibin Kang
Feb 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriel SilvaMozart Marins
Feb 9, 2018·The Journal of Craniofacial Surgery·Daniel GinatNicole Cipriani

❮ Previous
Next ❯

Citations

Feb 15, 2020·Tissue Engineering. Part B, Reviews·Eric R MolinaAntonios G Mikos
Jan 3, 2020·Molecular Medicine Reports·Yongjun ChenWensheng Xu
May 24, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Mariana Bastos Dos SantosLuis Octavio Regasini
Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna KozłowskaMirosław Anioł
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rimsha IrfanRahman Shah Zaib Saleem
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana MoreiraMadalena Pinto
Jul 3, 2021·Biomolecules·Yang OuyangQi Wu

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
Assay
electrophoresis
PCR
Protein Assay
transfection

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.