Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity

Journal of Advanced Pharmaceutical Technology & Research
Deepa Gupta, D K Jain

Abstract

Much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. Chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and antifungal agents etc. The presence of reactive α,β-unsaturated keto group in chalcones is found to be responsible for their biological activity. The rapid developments of resistance to antifungal agents, led to design, and synthesize the new antifungal agents. The derivatives of chalcones were prepared using Claisen-Schmidt condensation scheme with appropriate tetralone and aldehyde derivatives. Ten derivatives were synthesized and were biologically screened for antifungal activity. The newly synthesized derivatives of chalcone showed antifungal activity against fungal species, Microsporum gypseum. The results so obtained were superior or comparable to ketoconazole. It was observed that none of the compounds tested showed positive results for fungi Candida albicans nor against fungi Aspergillus niger. Chalcone derivatives showed inhibitory effect against M. gypseum species of fungus. It was found that among the chalcone derivatives so synthesized, two of them, that is, 4-chloro deri...Continue Reading

References

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Citations

Jan 28, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Krystyna OkoniewskaTomasz Grabowski
Dec 17, 2014·Journal de mycologie médicale·W Marek GołębiewskiA Michalczyk
Mar 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tzenge-Lien ShihChia-Feng Kuo
Feb 1, 2020·Archiv der Pharmazie·Peng ChengMaoqing Gong
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Jan 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marina Micaele Rodrigues SiqueiraHenrique Douglas Melo Coutinho
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Níura Madalena BilaMaria José Soares Mendes-Giannini
Jun 27, 2021·Journal of Molecular Modeling·Patricia R S WenceslauHamilton B Napolitano
Aug 28, 2021·Biomolecules·Hiba A JasimSatyajit D Sarker

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Methods Mentioned

BETA
NMR

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