Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Y L HsuC C Lin


Chalcones are discussed to represent cancer preventive food components in a human diet that is rich in fruits and vegetables. In this study, we examined chalcone (1,3-diphenyl-2-propenone) for its effect on proliferation in human breast cancer cell lines, MCF-7 and MDA-MB-231. The results showed that chalcone inhibited the proliferation of MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. Immunoblot assay showed that chalcone significantly decreased the expression of cyclin B1, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest. An enhancement in Fas/APO-1 and its two form ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), was responsible for the apoptotic effect induced by chalcone. In addition, chalcone also triggered the mitochondrial apoptotic signaling by increasing the amount of Bax and Bak and reducing the level of Bcl-2 and Bcl-X(L), and subsequently activated caspase-9 in MCF-7 and MDA-MB-231 cells. Taken together, our study suggests that the blockade of cell cycle progression and initiation of cell apoptotic system may participate in the antiproliferative act...Continue Reading


Dec 1, 1995·The Journal of Experimental Medicine·N KayagakiH Yagita
Mar 10, 1995·Science·S Nagata, P Golstein
Jan 1, 1994·Breast Cancer Research and Treatment·J Baselga, J Mendelsohn
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·G D Stoner, H Mukhtar
Oct 25, 2001·Blood·I Herr, K M Debatin
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Yoshiyuki Kimura, Kimiye Baba
Jul 9, 2004·Clinical and Experimental Pharmacology & Physiology·Ya-Ling HsuC C Lin
Feb 22, 2005·Current Medicinal Chemistry·M L GoX L Liu
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Keiichi TabataTakashi Suzuki


Apr 13, 2011·Genes & Nutrition·Barbora OrlikovaMarc Diederich
Oct 19, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Pierre ChampelovierAhcène Boumendjel
Apr 24, 2008·Clinical and Experimental Pharmacology & Physiology·Jen-Yu HungMing-Shyan Huang
Dec 4, 2012·International Journal of Molecular Sciences·Ewelina SzliszkaWojciech Krol
Mar 24, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·V Raja Solomon, Hoyun Lee
Jul 21, 2011·Steroids·Abid H BandayBashir A Ganaie
Jan 25, 2011·Journal of Photochemistry and Photobiology. B, Biology·Y YesuthangamR Murugesan
Aug 24, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Noor HasimaKhalijah Awang
Jul 8, 2010·Bioorganic & Medicinal Chemistry·Anindra SharmaRama P Tripathi
May 18, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chenghua LouBaochang Cai
Jan 1, 2008·Chemico-biological Interactions·Elga Heloísa AlbertonFátima Regina Mena Barreto Silva
Aug 21, 2010·Archiv der Pharmazie·Haiyong HanSeth D Rose
Oct 11, 2011·Archiv der Pharmazie·Lijun XiePing Gong
Mar 26, 2016·Chemico-biological Interactions·Lucas Felipe Fernandes BittencourtCláudia Beatriz Nedel
Aug 19, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Rajamani RajaA SubbiahPandi
Jun 17, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M JagadeeshTae Kyu Kim
Jul 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·David DrutovicJan Mojzis
Apr 9, 2013·Chemico-biological Interactions·Sun Young KimAree Moon
May 26, 2015·European Journal of Medicinal Chemistry·Debarshi Kar MahapatraVivek Asati
Mar 4, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Evelyn WinterTânia Beatriz Creczynski-Pasa
Jun 28, 2011·Biochemical Pharmacology·Barbora OrlikovaMarc Diederich
Mar 24, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yung-Tsuan HoJing-Gung Chung
Oct 12, 2016·Bioorganic & Medicinal Chemistry Letters·Florian SchmittRainer Schobert
Aug 18, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewelina SzliszkaWojciech Krol
Dec 25, 2018·Journal of Drug Targeting·Dana ElkhalifaAshraf Khalil
May 24, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Mariana Bastos Dos SantosLuis Octavio Regasini
Aug 2, 2011·Chemical & Pharmaceutical Bulletin·Lijun XieYanfang Zhao
Dec 7, 2016·Pharmacological Reports : PR·Tatiana B FogaçaTiago Collares
Mar 23, 2017·Natural Products and Bioprospecting·Xiu-Juan YinJi-Jun Chen
Jan 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Joan VillenaAlejandro Madrid
Dec 16, 2019·European Journal of Medicinal Chemistry·Dana ElkhalifaAshraf Khalil

Related Concepts

FASLG protein, human
CASP9 protein, human
CCNB1 protein, human
Antineoplastic Agents
Mammary Neoplasms, Human
Cell Cycle
Cell Division Phases
Dose-Response Relationship, Drug
Membrane Glycoproteins

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.