Chalk and cheese: symptomatic hypocalcaemia during paediatric anti-tuberculous therapy

The Journal of Infection
David BurgnerSam Walters

Abstract

Standard anti-tuberculosis therapy may disrupt normal vitamin D metabolism and consequently calcium homeostasis, but this is previously unreported in paediatric patients. We describe two children developed symptomatic hypocalcaemia secondary to hypovitaminosis D, which had been precipitated by rifampicin and isoniazid. The complex relationship between tuberculosis, anti-tuberculosis therapy, vitamin D metabolism and calcium, together with the clinical implications, are discussed.

References

Jun 1, 1989·European Journal of Pediatrics·J Gerritsen, K Knol
Oct 1, 1988·The American Review of Respiratory Disease·G A Rook
Nov 1, 1993·Indian Journal of Pediatrics·G P MathurS Rastogi
May 14, 1998·Archives of Disease in Childhood·L P Ormerod
Oct 3, 2003·The Lancet Infectious Diseases·Delane Shingadia, Vas Novelli

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Citations

Sep 16, 2004·Journal of Paediatrics and Child Health·N DavidsonD Burgner
Jul 9, 2011·Wiener klinische Wochenschrift·Ayse Nur TorunTevfik Sabuncu
Jun 11, 2015·Journal of Chemotherapy·Ludovica FacchiniElena Chiappini
Jun 29, 2016·The Pediatric Infectious Disease Journal·Clare LeungClare Nourse

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