Challenge with ovalbumin antigen increases uterine and cervical contractile activity in sensitized guinea pigs

American Journal of Obstetrics and Gynecology
Egle BytautieneRobert E Garfield

Abstract

The aims of this study were to investigate the effects of ovalbumin challenge on uterine and cervical contractility, intrauterine pressure, and uterine electromyography activity in sensitized guinea pigs. Guinea pigs were sensitized by injection of ovalbumin-aluminum hydroxide suspension. Control animals were injected with the aluminum hydroxide suspension only. On days 55-57 of pregnancy, longitudinal uterine and cervical strips from guinea pigs were prepared for isometric tension recording. Nonpregnant guinea pigs were outfitted with telemetric transducers to record intrauterine pressure and uterine electromyography. Ovalbumin significantly increased contractility of uterine and cervical strips from sensitized versus nonsensitized animals. These effects were abolished by histamine H(1) receptor antagonist in uterine strips and by histamine H(1) receptor antagonist and a mast cell stabilizer in cervical strips from sensitized animals. Cyclooxygenase and 5-lipoxygenase inhibitors had no significant effect on the response to ovalbumin. Treatment with ovalbumin in vivo significantly increased intrauterine pressure and uterine electromyography activity in sensitized but not in nonsensitized, animals. Our findings indicate that typ...Continue Reading

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Citations

Jun 24, 2014·Cellular & Molecular Immunology·Nardhy Gomez-LopezMarcia Arenas-Hernandez
Apr 14, 2010·American Journal of Reproductive Immunology : AJRI·Iris OhelEyal Sheiner
Oct 1, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroSonia S Hassan
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Egle BytautieneRobert E Garfield
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Robert E GarfieldRoberto Romero
Nov 7, 2016·Obstetrics and Gynecology Clinics of North America·Elizabeth A Bonney

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