Challenges and Benefits of Repurposing Products for Use during a Radiation Public Health Emergency: Lessons Learned from Biological Threats and other Disease Treatments.

Radiation Research
Andrea L DiCarloPaul W Price

Abstract

The risk of a radiological or nuclear public health emergency is a major growing concern of the U.S. government. To address a potential incident and ensure that the government is prepared to respond to any subsequent civilian or military casualties, the U.S. Department of Health and Human Services and the Department of Defense have been charged with the development of medical countermeasures (MCMs) to treat the acute and delayed injuries that can result from radiation exposure. Because of the limited budgets in research and development and the high costs associated with bring promising approaches from the bench through advanced product development activities, and ultimately, to regulatory approval, the U.S. government places a priority on repurposing products for which there already exists relevant safety and other important information concerning their use in humans. Generating human data can be a costly and time-consuming process; therefore, the U.S. government has interest in drugs for which such relevant information has been established (e.g., products for another indication), and in determining if they could be repurposed for use as MCMs to treat radiation injuries as well as chemical and biological insults. To explore the...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K RiesbeckA Forsgren
Jul 1, 1988·International Journal of Radiation Oncology, Biology, Physics·W F WardN H Solliday
Mar 1, 1987·Journal of the American Academy of Dermatology·T G Kreindler
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A LewR Finberg
Jul 1, 1994·The American Journal of Tropical Medicine and Hygiene·J M DollK Gage
Nov 26, 1997·Antimicrobial Agents and Chemotherapy·A M SugarR J Chen
Jan 17, 2002·The Annals of Pharmacotherapy·G L North
May 1, 1965·Clinical Pharmacology and Therapeutics·J SHESKIN
Apr 2, 2004·Nature Reviews. Cancer·J Blake BartlettAngus G Dalgleish
Jun 16, 2004·Annals of Internal Medicine·Jamie K WaselenkoUNKNOWN Strategic National Stockpile Radiation Working Group
Aug 3, 2004·Nature Reviews. Drug Discovery·Ted T Ashburn, Karl B Thor
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea MeyerhoffDianne Murphy
Jun 22, 2005·Radiation Research·Alison Deckhut AugustineSara Rockwell
Feb 9, 2006·Blood Cells, Molecules & Diseases·John H GriffinBerislav V Zlokovic
Oct 3, 2007·Cancer Research·Marjan BoermaMartin Hauer-Jensen
Sep 24, 2009·Journal of Biomolecular Screening·Keith A HouckEllen L Berg
Nov 26, 2009·International Journal of Radiation Oncology, Biology, Physics·Swarajit N GhoshMeetha Medhora
Jan 13, 2010·Health Physics·G David Ledney, Thomas B Elliott
May 18, 2010·International Journal of Radiation Biology·David M ThomasChristina K Haston
Aug 25, 2010·Drug Discovery Today·Nicola Dimitri
Dec 1, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C SahakitrungruangA Rojanasakul
Dec 15, 2010·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Nathaniel HaferRichard J Hatchett
Feb 25, 2011·PLoS Neglected Tropical Diseases·Robert Colby LaytonFrederick Koster
Aug 13, 2011·Blood·L Bik ToKirsten E Herbert
Oct 18, 2011·Disaster Medicine and Public Health Preparedness·Thomas K Zink
Nov 23, 2011·International Journal of Radiation Oncology, Biology, Physics·Eric P CohenJohn E Moulder
Feb 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Jordan KharofaElizabeth Gore
May 24, 2012·The New England Journal of Medicine·V Marco RanieriUNKNOWN PROWESS-SHOCK Study Group
Jul 24, 2012·Nature Neuroscience·Ji Won UmStephen M Strittmatter

❮ Previous
Next ❯

Citations

Mar 22, 2019·The Cancer Journal·Mohammad K KhanStephen J Kron
May 15, 2021·Frontiers in Pharmacology·Meetha MedhoraAniko Szabo
Aug 18, 2021·International Journal of Radiation Biology·Vijay K Singh, Thomas M Seed
Jun 22, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Andrea L DiCarloC Norman Coleman

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
flow cytometry
X-ray

Software Mentioned

BioMap
Mozobil
BARDA

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.