Challenges and new approaches to proving the existence of muscle synergies of neural origin.

PLoS Computational Biology
Jason J Kutch, Francisco J Valero-Cuevas

Abstract

Muscle coordination studies repeatedly show low-dimensionality of muscle activations for a wide variety of motor tasks. The basis vectors of this low-dimensional subspace, termed muscle synergies, are hypothesized to reflect neurally-established functional muscle groupings that simplify body control. However, the muscle synergy hypothesis has been notoriously difficult to prove or falsify. We use cadaveric experiments and computational models to perform a crucial thought experiment and develop an alternative explanation of how muscle synergies could be observed without the nervous system having controlled muscles in groups. We first show that the biomechanics of the limb constrains musculotendon length changes to a low-dimensional subspace across all possible movement directions. We then show that a modest assumption--that each muscle is independently instructed to resist length change--leads to the result that electromyographic (EMG) synergies will arise without the need to conclude that they are a product of neural coupling among muscles. Finally, we show that there are dimensionality-reducing constraints in the isometric production of force in a variety of directions, but that these constraints are more easily controlled for...Continue Reading

References

Dec 1, 1993·Journal of Neurophysiology·A J FuglevandA E Patla
Jan 1, 1993·Journal of Biomechanics·A D Kuo, F E Zajac
Oct 31, 1998·Journal of Biomechanics·F J Valero-CuevasC G Burgar
Apr 9, 1999·Nature Neuroscience·M C TreschE Bizzi
Apr 19, 2000·Journal of Cognitive Neuroscience·E P LoebF A Mussa-Ivaldi
Feb 4, 2003·Nature Neuroscience·Andrea d'AvellaEmilio Bizzi
Aug 9, 2003·Experimental Brain Research·Vijaya KrishnamoorthyVladimir M Zatsiorsky
Sep 3, 2004·Journal of Neurophysiology·Lena H Ting, Jane M Macpherson
Feb 17, 2005·Journal of Biomechanics·Francisco J Valero-Cuevas
Jun 16, 2006·Journal of Neurophysiology·Gelsy Torres-OviedoLena H Ting
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea d'AvellaFrancesco Lacquaniti
Dec 13, 2006·Journal of Biomechanics·J Lucas McKayLena H Ting
Dec 22, 2006·Journal of Neurophysiology·Terence D Sanger
Jan 6, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vijaya KrishnamoorthyMark L Latash
Jul 27, 2007·Journal of Neurophysiology·Gelsy Torres-Oviedo, Lena H Ting
Jan 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon A OverduinEmilio Bizzi
Feb 14, 2008·IEEE Transactions on Bio-medical Engineering·Robert H ClewleyFrancisco J Valero-Cuevas
Sep 19, 2008·Journal of Neurophysiology·Jason J KutchWilliam Z Rymer
Dec 17, 2008·Journal of Neurophysiology·James M Wakeling, Tamara Horn
Feb 21, 2009·Advances in Experimental Medicine and Biology·Francisco J Valero-Cuevas
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vikram S ChibFerdinando A Mussa-Ivaldi
Apr 17, 2009·Journal of Neurophysiology·Francisco J Valero-CuevasEmanuel Todorov
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Max BernikerMatthew C Tresch
Jul 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin G KeenanFrancisco J Valero-Cuevas
Oct 16, 2009·Current Opinion in Neurobiology·Matthew C Tresch, Anthony Jarc
Nov 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vincent C K CheungEmilio Bizzi
Dec 4, 2009·Annals of Biomedical Engineering·Edith M ArnoldScott L Delp
Jan 1, 2009·IEEE Reviews in Biomedical Engineering·Francisco J Valero-CuevasEvangelos A Theodorou

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Citations

Dec 5, 2013·Physiological Reports·Christian MaurerBenno M Nigg
Nov 6, 2012·Medical & Biological Engineering & Computing·Thomas J Burkholder, Keith W van Antwerp
Feb 13, 2016·Frontiers in Computational Neuroscience·M Hongchul Sohn, Lena H Ting
Apr 30, 2015·The Journal of Physiology·Seungmoon Song, Hartmut Geyer
Aug 25, 2015·Journal of Biomechanics·Cole S SimpsonLena H Ting
Dec 1, 2015·Frontiers in Bioengineering and Biotechnology·Shota Hagio, Motoki Kouzaki
Oct 27, 2015·Frontiers in Computational Neuroscience·Reza Sharif RazavianJohn McPhee
Aug 26, 2014·Human Movement Science·Georg HettichThomas Mergner
Apr 29, 2015·Current Opinion in Neurobiology·Simon F Giszter
Mar 6, 2015·Frontiers in Human Neuroscience·Pietro MorassoJacopo Zenzeri
Oct 4, 2014·Frontiers in Computational Neuroscience·Friedl De GrooteJacques Duysens
Dec 19, 2014·Frontiers in Computational Neuroscience·Anantharaman GopalakrishnanAndrew T M Phillips
Jul 9, 2014·Frontiers in Computational Neuroscience·Naveen Kuppuswamy, Christopher M Harris
Jun 17, 2016·Journal of Neuroengineering and Rehabilitation·Fabio OscariGiulio Rosati
May 29, 2013·Gait & Posture·Vennila KrishnanMark D Grabiner
Oct 7, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Francesca LunardiniAlessandra Pedrocchi
Oct 12, 2016·Journal of Neuroengineering and Rehabilitation·Francisco J Valero-CuevasRobert Riener
Oct 14, 2016·Scientific Reports·Vittorio CaggianoEmilio Bizzi
Feb 16, 2018·Frontiers in Human Neuroscience·Marije GoudriaanKaat Desloovere
Oct 12, 2017·Journal of Neuroengineering and Rehabilitation·Francisco J Valero-Cuevas, Marco Santello
Feb 1, 2018·Journal of Motor Behavior·Jinsook RohKevin D Wilger
Jul 1, 2017·Journal of Neurophysiology·Christopher M Laine, Francisco J Valero-Cuevas
Jan 18, 2017·Journal of Neural Engineering·Kian JalaleddiniFrancisco J Valero-Cuevas
Feb 22, 2018·Applied Bionics and Biomechanics·Ana Lucia Cruz RuizGeorges Dumont
Jul 19, 2018·Journal of Neurophysiology·Kevin A MazurekM Hongchul Sohn
Jan 3, 2019·PloS One·Dimitar Stanev, Konstantinos Moustakas
Jan 14, 2018·Scientific Reports·Roberto PreveteGiovanni Pezzulo
Jul 26, 2019·Developmental Neurorehabilitation·Simona PortaroDemetrio Milardi
Jan 17, 2014·Journal of Neurophysiology·Karl E ZelikFrancesco Lacquaniti
Sep 5, 2014·Journal of Neural Engineering·Mark Ison, Panagiotis Artemiadis
Jul 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tomohiko TakeiKazuhiko Seki
Dec 7, 2019·Experimental Brain Research·Laura PellegrinoMaura Casadio
Nov 30, 2019·European Journal of Applied Physiology·Enzo HollvilleGiuseppe Rabita
Jun 7, 2013·Medicine and Science in Sports and Exercise·Hendrik EndersBenno M Nigg

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Methods Mentioned

BETA
PCA

Software Mentioned

OpenSim
Neuromuscular Models Library

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