Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss

Nanomedicine : Nanotechnology, Biology, and Medicine
Mohammad N KayyaliDaqing Li

Abstract

The development of inner ear gene carriers and delivery systems has enabled genetic defects to be repaired and hearing to be restored in mouse models. Today, promising advances in translational therapies provide confidence that targeted molecular therapy for inner ear diseases will be developed. Unfortunately, the currently available non-invasive modalities, such as Computerized Tomography scan or Magnetic Resonance Imaging provide insufficient resolution to identify most pathologies of the human inner ear, even when the current generation of contrast agents is utilized. The development of targeted contrast agents may play a critical role in determining the cause of, and treatment for, sensorineural hearing loss. Such agents should be able to pass through the cochlea barriers, possess minimal cytotoxicity, and easily conjugate to a targeting agent, without distorting the anatomic details. This review focuses on a series of contrast agents which may fit these criteria for potential clinical application.

Citations

May 23, 2020·Stem Cell Reports·Pei-Ciao TangRick F Nelson
May 26, 2021·Journal of the American Academy of Audiology·Jenna E BergmanAdrien A Eshraghi
Jul 3, 2021·Journal of Clinical Medicine·Reza KaboodkhaniFeridoun Karimi-Busheri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.