Challenges and opportunities in implementing pharmacogenomics testing in the clinics

Personalized Medicine
Jon R WislerClay B Marsh

Abstract

The field of pharmacogenomics aims to incorporate individual patient genomic information into treatment selection. This is a rapidly evolving field with significant clinical promise. Implementation into clinical practice has several challenges that must be overcome. Genomics-based information encompasses large databases and requires expert knowledge for interpretation. Existing research suggests there are already several areas where pharmacogenomics-based decision-making is ripe for adoption into clinical practice. Impediments exist that must be overcome prior to large-scale implementation of existing pharmacogenomics-based therapies. There are several institutions and corporations at the forefront of implementation that are leading the development; however, larger systems-based approaches will be necessary. This article will discuss some of the present successes and future challenges that are necessary to overcome in order to implement a more patient-centered healthcare system.

References

Jun 3, 1983·Science·V L Wilson, P A Jones
Mar 17, 1999·British Journal of Pharmacology·A A WeberK Schrör
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Nov 17, 2001·JAMA : the Journal of the American Medical Association·K A PhillipsW Sadee
Dec 26, 2001·Nucleic Acids Research·Micheal HewettTeri E Klein
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Mitchell K HigashiAllan E Rettie
Feb 7, 2004·Nature·Tao LiDarrel W Stafford
May 28, 2004·Nature·Jeremy SchmutzRichard M Myers
Oct 22, 2004·Nature·UNKNOWN International Human Genome Sequencing Consortium
Jan 6, 2005·Journal of the National Cancer Institute·Yan JinDavid A Flockhart
Jan 18, 2005·Journal of the American College of Cardiology·Victor L SerebruanyEric J Topol
Jun 3, 2005·The New England Journal of Medicine·Mark J RiederAllan E Rettie
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzJames N Ingle
Jan 5, 2006·European Journal of Human Genetics : EJHG·Marcus E PembreyUNKNOWN ALSPAC Study Team
Sep 20, 2006·Cancer Research·Yuki TsuchiyaTsuyoshi Yokoi
Sep 21, 2007·Clinical Pharmacology and Therapeutics·M P GoetzM M Ames
Nov 9, 2007·Circulation·Jeffrey L AndersonUNKNOWN Couma-Gen Investigators
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Ezekiel J Emanuel, Victor R Fuchs
Dec 17, 2008·Breast Cancer Research and Treatment·Adedayo A OnitiloYan Jin
Dec 25, 2008·The New England Journal of Medicine·Tabassome SimonUNKNOWN French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
Feb 12, 2009·Pharmacogenomics·James J CrowleyHoward L McLeod
Mar 7, 2009·Journal of the American College of Cardiology·Dirk SibbingNicolas von Beckerath
Apr 21, 2009·Nature Reviews. Cardiology·Jean-Sébastien Hulot, Valentin Fuster
Jul 8, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yu-Zhuo PanAi-Ming Yu
Aug 19, 2009·Annals of Internal Medicine·Michael H Rosove, Wayne W Grody
Aug 27, 2009·JAMA : the Journal of the American Medical Association·Alan R ShuldinerPaul A Gurbel
Sep 12, 2009·Journal of the American College of Cardiology·Francisco MarínDominick J Angiolillo
Dec 18, 2009·PharmacoEconomics·Lisa M MeckleyDavid L Veenstra
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Amanda R PatrickNiteesh K Choudhry
Apr 27, 2010·Pharmacogenomics·Magnus Ingelman-Sundberg, Alvin Gomez
Apr 27, 2010·Nature Genetics·Jason Z LiuJonathan Marchini
May 11, 2010·Nature Genetics·Serena SannaFrancesco Cucca
Aug 10, 2010·Clinical Trials : Journal of the Society for Clinical Trials·Jungnam JooJonas H Ellenberg

❮ Previous
Next ❯

Methods Mentioned

BETA
chips
electrophoresis
genotyping
pharmacotherapy

Software Mentioned

PGRN
Celera
EU
GIFT
COAG
PharmGKB
PACT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
O Bredeţean, A D Ciochină
Expert Review of Pharmacoeconomics & Outcomes Research
Ann M Moyer, Pedro J Caraballo
© 2022 Meta ULC. All rights reserved