Challenges and solutions for the delivery of biotech drugs--a review of drug nanocrystal technology and lipid nanoparticles

Journal of Biotechnology
Rainer H Müller, Cornelia M Keck

Abstract

Biotechnology allows tailor-made production of biopharmaceuticals and biotechnological drugs; however, many of them require special formulation technologies to overcome drug-associated problems. Such potential challenges to solve are: poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome such delivery problems, i.e. drug nanocrystals, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid-drug conjugate (LDC) nanoparticles, examples of drugs are given. As a recently developed targeting principle, the concept of differential protein adsorption is described (PathFinder Technology) using as example delivery to the brain.

References

Jan 1, 1979·Advances in Pharmacology and Chemotherapy·K J WidderD F Ranney
Oct 1, 1992·Clinical Pharmacokinetics·R JanknegtD J Crommelin
Sep 18, 1989·Biochimica Et Biophysica Acta·S M Moghimi, H M Patel
Jan 1, 1986·Methods in Enzymology·D R Absolom
May 1, 1968·British Medical Bulletin·A D Bangham, D A Haydon
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P S GillA M Levine
Jul 1, 1994·Trends in Pharmacological Sciences·T M Allen
Sep 1, 1993·Chemistry and Physics of Lipids·A D Bangham
Apr 11, 1996·Nature·D D Lasic
May 1, 1997·The Journal of Antimicrobial Chemotherapy·Y ShadkhanD Lichtenberg
May 1, 1998·Pharmaceutical Research·Z ShahrokhM F Powell
Jun 11, 1999·International Journal of Pharmaceutics·B Carreno-GómezA T Florence
Mar 4, 2000·International Journal of Pharmaceutics·K P KrauseR H Müller
May 19, 2000·Antimicrobial Agents and Chemotherapy·L ZarifR J Mannino
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla
Jul 25, 2000·Journal of Pharmaceutical Sciences·W N Charman
Aug 10, 2000·Nature Biotechnology·G Walsh
Mar 17, 2001·Advanced Drug Delivery Reviews·H TakeuchiY Kawashima
Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
May 17, 2001·Antimicrobial Agents and Chemotherapy·N SchölerO Liesenfeld
Sep 29, 2001·Advanced Drug Delivery Reviews·C J Porter, W N Charman
Jan 14, 2003·Pharmaceutical Research·Norbert Rasenack, Bernd W Müller
Jan 29, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gary Walsh
Mar 5, 2003·International Journal of Pharmaceutics·O KayserS L Croft
Jul 3, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Aslihan Akkar, Rainer H Müller
Aug 2, 2003·Nature Biotechnology·Gary Walsh

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Citations

Jun 23, 2010·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Valentina BelloElisabetta Borsella
Oct 25, 2008·Critical Reviews in Food Science and Nutrition·David Julian McClementsYeonhwa Park
Jun 2, 2009·Critical Reviews in Food Science and Nutrition·David Julian McClementsJochen Weiss
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·David Julian McClements, Jiajia Rao
Feb 21, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ketan HippalgaonkarSoumyajit Majumdar
Aug 29, 2013·Journal of Biomedical Nanotechnology·Vuk Uskoković
Apr 6, 2007·AAPS PharmSciTech·Neera JainSamuel H Yalkowsky
Sep 22, 2010·International Journal of Nanomedicine·Zaida Urbán-MorlánDavid Quintanar-Guerrero
Jul 29, 2011·International Journal of Nanomedicine·Yonglu WangPing Wei
Aug 1, 2012·International Journal of Nanomedicine·Zhen-Hai ZhangHui-Xia Lv
Aug 29, 2007·International Journal of Nanomedicine·Li-Jiuan Shen, Fe-Lin Lin Wu
Jan 15, 2014·International Journal of Pharmaceutics·Nehal IbrahimFrançoise Nepveu
Jul 1, 2010·Therapeutic Delivery·Evren H GokceEliana B Souto
Apr 11, 2014·Chemistry and Physics of Lipids·Elham RostamiKobra Omidfar
Apr 16, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Indu Pal Kaur, Harinder Singh
Feb 26, 2014·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Neha SinghIndu Pal Kaur
Oct 12, 2013·Biotechnology Advances·Shutao Guo, Leaf Huang
Mar 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vivek K PawarManish K Chourasia
May 12, 2012·Archives of Toxicology·Robert LandsiedelFranz Oesch
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Govind Soni, Khushwant S Yadav
Oct 1, 2013·Drug Delivery and Translational Research·Sandip S ChavanPradeep R Vavia
Dec 14, 2011·Expert Review of Vaccines·Delaram Doroud, Sima Rafati
Dec 21, 2011·Drug Development and Industrial Pharmacy·Cong-Cong Wei, Zhi-Qiang Ge
Dec 24, 2011·Journal of Drug Targeting·Yue LiuQiang Zhang
Dec 19, 2009·Expert Opinion on Drug Delivery·Maria Luisa Bondì, Emanuela Fabiola Craparo
Feb 20, 2014·Drug Delivery·Bita TaghizadehZaynab Derakhshani
Mar 15, 2015·Journal of Drug Targeting·Sanaul MustafaV Kusum Devi
Sep 29, 2011·Drug Development and Industrial Pharmacy·Shuzhang DuChaofeng Zhang
Apr 6, 2013·Drug Development and Industrial Pharmacy·Kalle SigfridssonMarie Strimfors
Dec 22, 2007·Expert Opinion on Drug Delivery·Ben J Boyd

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