Challenges associated in stability of food grade nanoemulsions

Critical Reviews in Food Science and Nutrition
P KarthikC Anandharamakrishnan


Food grade nanoemulsions are being increasingly used in the food sector for their physico-chemical properties towards efficient encapsulation, entrapment of bioactive compounds, solubilization, targeted delivery, and bioavailability. Nanoemulsions are considered as one of the important vehicles for the sustained release of food bioactive compounds due to their smaller size (nm), increased surface area, and unique morphological characteristics. Nanoemulsification is an ideal technique for fabricating the bioactive compounds in a nano form. Formation and stabilization of nanoemulsion depends on the physi-cochemical characteristics of its constituents including oil phase, aqueous phase, and emulsifiers. This review is mainly focused on the instability mechanisms of nanoemulsion such as flocculation, Ostwald ripening, creaming, phase separation, coalescence, and sedimentation. Further, the major factors associated with these instability mechanisms like ionic strength, temperature, solubilization, particle size distribution, particle charge, pH strength, acid stability, and heat treatment are also discussed. Finally, safety issues of food grade nanoemulsions are highlighted.


Dec 6, 2000·Advanced Drug Delivery Reviews·M J Lawrence, G D Rees
Mar 10, 2001·Ultrasonics Sonochemistry·B AbismaïlC Gourdon
Jul 11, 2003·Biomaterials·Béatrice HeurtaultJean-Pierre Benoit
Sep 5, 2003·International Journal of Pharmaceutics·I RolandB Evrard
Mar 18, 2004·Advances in Colloid and Interface Science·Ignác Capek
Apr 10, 2004·Advances in Colloid and Interface Science·Tharwat TadrosC Solans
Apr 13, 2005·Clinical Techniques in Small Animal Practice·Jeannette S MesserMary A McLoughlin
Aug 15, 2006·Journal of Colloid and Interface Science·Weirong LiuJian Xu
Jul 6, 2007·International Journal of Food Microbiology·Paula C TeixeiraJoão Paulo Ferreira
Sep 18, 2007·Regulatory Toxicology and Pharmacology : RTP·Werner I HagensAdriënne J A M Sips
Apr 1, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicolas AntonPatrick Saulnier
Oct 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Tim J WoosterPeerasak Sanguansri
Nov 26, 2008·Regulatory Toxicology and Pharmacology : RTP·Hans BouwmeesterAdriënne J A M Sips
Jan 13, 2009·Trends in Biotechnology·Nesli Sozer, Jozef L Kokini
Mar 27, 2009·Ultrasonics Sonochemistry·T S H LeongM Ashokkumar
May 21, 2009·International Journal of Pharmaceutics·Nicolas Anton, Thierry F Vandamme
Sep 8, 2009·Journal of Agricultural and Food Chemistry·Yan LiDavid Julian McClements
Dec 8, 2010·Journal of Agricultural and Food Chemistry·Sung Je LeeDavid Julian McClements
Jan 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Thomas DelmasJérôme Bibette
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·David Julian McClements, Jiajia Rao
Apr 28, 2011·Journal of Agricultural and Food Chemistry·Khalid ZianiDavid Julian McClements
Jul 5, 2011·Pest Management Science·C H AnjaliNatarajan Chandrasekaran
Aug 3, 2011·Archives of Oral Biology·Karthikeyan RamalingamValerie A Lee
Oct 27, 2011·Journal of Agricultural and Food Chemistry·Mariarenata SessaFrancesco Donsì
Sep 8, 2012·Ultrasonics Sonochemistry·Vijayalakshmi GhoshNatarajan Chandrasekaran
Sep 11, 2012·Journal of Basic Microbiology·Saranya SugumarNatarajan Chandrasekaran
Oct 31, 2012·Food Chemistry·Jiajia Rao, David Julian McClements
Jan 22, 2013·Journal of Agricultural and Food Chemistry·Rong LiangQingrong Huang
May 8, 2013·Journal of the Science of Food and Agriculture·Jiajia RaoDavid Julian McClements
Sep 13, 2013·Journal of Food Science·In-Hah KimSea C Min
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