Challenges associated with regeneration of orbital floor bone

Tissue Engineering. Part B, Reviews
Martha W BetzJohn P Fisher

Abstract

Orbital floor fractures are a serious consequence of craniofacial trauma and account for ∼60%-70% of all orbital fractures. Unfortunately, the body's natural response to orbital floor defects generally may not restore proper function and facial aesthetics, which is complicated by the thin bone and adjacent sinuses. Current clinical treatments include alloplastic implants and autologous grafts; however, each has associated disadvantages and sequelae. This review has outlined necessary components for a successful tissue-engineered construct for orbital floor repair. In addition, current successes and progress in the literature specific to orbital floors and craniofacial research have been reviewed. Finally, challenges and future directions have been described.

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Citations

Oct 12, 2010·Tissue Engineering. Part C, Methods·Andrew B Yeatts, John P Fisher
Jul 10, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Marcin Kozakiewicz
Dec 18, 2013·Acta Biomaterialia·Francesco BainoMonica Ferraris
Jun 10, 2011·Acta Biomaterialia·Francesco Baino
Mar 31, 2015·Clinical Hemorheology and Microcirculation·Mike A GevenDirk W Grijpma
Jun 1, 2014·Acta Biomaterialia·Francesco Baino, Chiara Vitale-Brovarone
Oct 18, 2016·Ophthalmic Plastic and Reconstructive Surgery·Michelle T SunDinesh Selva
Jul 7, 2011·Current Opinion in Ophthalmology·Emily M Bratton, Vikram D Durairaj

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