Challenges for biophysical modeling of microstructure.

Journal of Neuroscience Methods
Ileana O JelescuKurt G Schilling

Abstract

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifying both hurdles that have been already overcome and outstanding issues. First, we describe the critical initial task of selecting which features of tissue microstructure can be estimated using a model and which acquisition protocol needs to be implemented to make the estimation possible. The model performance should necessarily be tested in realistic numerical simulations and in experimental data - adapting the fitting strategy accordingly, and parameter estimates should be validated against complementary techniques, when/if available. Secondly, the model performance and validity should be explored in pathological conditions, and, if appropriate, dedicated models for pathology should be developed. We build on examples from tumors, ischemia and demyelinating diseases. We then discuss the challenges associated with clinical translation and added value. Finally, we single out four major unresolved challenges that are related to: the availability of a microstructural ground truth,...Continue Reading

References

May 1, 1992·Stroke; a Journal of Cerebral Circulation·H BenvenisteG A Johnson
May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E MoseleyP R Weinstein
Nov 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Beaulieu, P S Allen
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L LatourC H Sotak
Apr 1, 1996·Journal of Magnetic Resonance. Series B· de Swiet TM, P P Mitra
Nov 1, 1995·NMR in Biomedicine·A SzaferJ C Gore
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K P WhittallD W Paty
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J StaniszR M Henkelman
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Q DuongJ J Neil
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J BasserA Aldroubi
Dec 1, 2000·Journal of Magnetic Resonance·M SchachterJ C Gore
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Q DuongJ J Neil
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark A GriswoldAxel Haase
Sep 28, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S TuchVan J Wedeen
Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew D SilvaChristopher H Sotak
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark D DoesJohn C Gore
Aug 27, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James D QuirkJeffrey J Neil
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Sep 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chih-Liang ChinDavid B Hackney
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher D KroenkeDmitriy A Yablonskiy
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yaniv AssafPeter J Basser
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James A GoodmanJeffrey J Neil
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Jun 1, 2005·NeuroImage·Daniel C Alexander, Gareth J Barker
Jan 6, 2006·Annals of the New York Academy of Sciences·Daniel C Alexander
Dec 26, 2006·NeuroImage·Sune N JespersenDmitriy A Yablonskiy
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maxime DescoteauxRachid Deriche
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael LustigJohn M Pauly
Nov 21, 2007·Journal of Magnetic Resonance·Els FieremansIgnace Lemahieu
Dec 22, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James A GoodmanJeffrey J Neil
Feb 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy H MurphyRichard Liu
May 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yaniv AssafPeter J Basser
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel C Alexander
Mar 11, 2009·IEEE Transactions on Medical Imaging·Matt G Hall, Daniel C Alexander
May 1, 2009·Brain : a Journal of Neurology·Daniel BarazanyYaniv Assaf

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Citations

Nov 27, 2020·Journal of Neuroscience Methods·Filip SzczepankiewiczMarkus Nilsson
Oct 24, 2020·Journal of Neuroscience Methods·Dmitry S Novikov
Mar 23, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ilana R LeppertChristine L Tardif
Mar 25, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Merry ManiMathews Jacob
Jul 31, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rafael Neto HenriquesNoam Shemesh
Aug 28, 2021·Journal of Neuroscience Methods·Hu Cheng, Vince Calhoun

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