Challenges for environmental epidemiology research: are biomarker concentrations altered by kidney function or urine concentration adjustment?

Journal of Exposure Science & Environmental Epidemiology
Virginia WeaverEllen K Silbergeld

Abstract

Biomonitoring has become a standard approach for exposure assessment in occupational and environmental epidemiology. The use of biological effect markers to identify early adverse changes in target organs has also become widely adopted. However, the potential for kidney function to affect biomarker levels in the body and the optimal approach to adjustment of biomarker concentrations in spot urine samples for hydration status are two important but underappreciated challenges associated with biomarker use. Several unexpected findings, such as positive associations between urine nephrotoxicant levels and estimated glomerular filtration rate (eGFR), have been reported recently in research using biomarkers. These and other findings, discussed herein, suggest an impact of kidney glomerular filtration or tubule processing on biomarker levels. This is more commonly raised in the context of decreased kidney filtration, traditionally referred to as reverse causality; however, recent data suggest that populations with normal kidney filtration may be affected as well. Misclassification bias would result if biomarkers reflect kidney function as well as either exposures or early biological effect outcomes. Furthermore, urine biomarker associ...Continue Reading

References

May 1, 1992·Kidney International·F Khalil-ManeshV J Rosen
Mar 1, 1995·Occupational and Environmental Medicine·A BernardR Lauwerys
Oct 1, 1993·American Industrial Hygiene Association Journal·M F BoenigerJ Rosenberg
Apr 17, 1996·JAMA : the Journal of the American Medical Association·R KimH Hu
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·V D NenovB M Brenner
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gunter WolfFuad N Ziyadeh
Jan 24, 2003·The New England Journal of Medicine·Philip A Marsden
Jul 29, 2003·Occupational and Environmental Medicine·V M WeaverB S Schwartz
Jul 9, 2005·Environmental Health Perspectives·Bruce P LanphearRussell Roberts
Aug 4, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Y SuwazonoM Vahter
Nov 3, 2005·Environmental Health Perspectives·Agneta AkessonStaffan Skerfving
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 29, 2009·Current Opinion in Nephrology and Hypertension·Wayne D Comper, Leileata M Russo
Jun 18, 2010·Kidney International·Sushrut S WaikarJoseph V Bonventre
Jun 29, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Emmy Van KerkhoveQuirine Swennen
Oct 15, 2010·Kidney International·Marie Evans, Carl-Gustaf Elinder
Jun 10, 2011·International Archives of Occupational and Environmental Health·Magnus AkerstromGerd Sallsten
Aug 30, 2011·Environmental Research·Virginia M WeaverBrian S Schwartz
Apr 12, 2012·Cardiorenal Medicine·Hussein YassineSerrine S Lau
Jul 31, 2012·Occupational and Environmental Medicine·Rebecca ShelleyVirginia M Weaver
Jan 25, 2013·Environmental Health : a Global Access Science Source·Johan Nilsson SommarIngvar A Bergdahl
Mar 5, 2013·Toxicology and Applied Pharmacology·Magnus AkerstromGerd Sallsten
Mar 14, 2013·Environmental Health Perspectives·Deborah J WatkinsGregory A Wellenius
Apr 18, 2013·Journal of Exposure Science & Environmental Epidemiology·Rebecca ShelleyVirginia M Weaver
Dec 25, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph A AbdelmalekDena E Rifkin
Mar 7, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Lesa L AylwardRuth Bevan

❮ Previous
Next ❯

Citations

Jul 20, 2016·Environmental Research·M Cárdenas-GonzálezV S Vaidya
Aug 12, 2016·International Archives of Occupational and Environmental Health·Anne LotzAlbrecht Seidel
Oct 16, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Darcy K WeidemannJeffrey J Fadrowski
Oct 23, 2016·Environmental Research·Anja StajnkoMilena Horvat
Jan 18, 2017·Current Environmental Health Reports·Katie M O'BrienJessie P Buckley
Jun 11, 2016·Environmental Health Perspectives·Melissa M SmarrGermaine M Buck Louis
Nov 13, 2018·Journal of Toxicology and Environmental Health. Part a·Dong Hyun KimByung-Mu Lee
Jun 24, 2015·Nature Reviews. Nephrology·Anglina KatariaHoward Trachtman
Jan 3, 2020·Journal of Toxicology and Environmental Health. Part a·Gary L DiamondLisa D Ingerman
Mar 7, 2020·Toxics·Soisungwan SatarugDavid A Vesey
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka Tkaczyk, Piotr Jedziniak
Sep 14, 2017·Environmental Health : a Global Access Science Source·Hongyu WangAlfred Bernard
Dec 1, 2017·Environmental Science and Pollution Research International·Saeed ParastarRoya Kelishadi
Aug 24, 2018·Metabolites·Markus RotterRui Wang-Sattler
Sep 25, 2019·Metabolites·Ana K Rosen VollmarCaroline H Johnson
May 20, 2020·Journal of Exposure Science & Environmental Epidemiology·Ana K Rosen VollmarAnne Marie Z Jukic
Aug 19, 2017·Archives of Environmental Contamination and Toxicology·Sang-Yong EomJung-Duck Park
Jun 9, 2018·Journal of Exposure Science & Environmental Epidemiology·Susan MacPhersonMandy Fisher
Sep 25, 2017·Environmental Monitoring and Assessment·Youssef MouneimneHani Tamim
May 6, 2021·Environment International·Melanie H JacobsonLeonardo Trasande
May 26, 2021·Environment International·Chu-Chih ChenMing-Tsang Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.