Challenges for the implementation of high-throughput testing and liquid biopsies in personalized medicine cancer trials

Personalized Medicine
Loic VerlingueChristophe Le Tourneau

Abstract

During recent decades, major advances in the comprehension of biology and in biotechnologies have paved the way for what is commonly named personalized medicine. For cancer therapy, personalized medicine represents a paradigm shift in which patient treatment is based on biology in addition to histology and tumor location. Here, we report the major personalized medicine trials in oncology that are either based on molecular alterations from tumor tissue or from circulating blood markers. We next review important challenges facing the implementation of personalized medicine in daily clinical practice, including tumor heterogeneity, reliability of high-throughput technologies, the key role of bioinformatics and the assessment of biomarkers and synthetic models, in order to use big data in actual cancer biology.

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Citations

Sep 6, 2018·Therapeutic Advances in Medical Oncology·Raffaele PalmirottaFranco Silvestris
May 1, 2021·Cancers·Lingyi Kong, Andrew C Birkeland

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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT01771458
NCT01856296
NCT00382018
NCT01349842
NCT01710605
NCT01619111
NCT01791309

Software Mentioned

CellSearch

Related Concepts

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