Challenges in antibody titration for ABO-incompatible renal transplantation.

Vox Sanguinis
Htar KahlyarThiru Vanniasinkam

Abstract

Accurate and regular monitoring of anti-A and anti-B titres pre- and post-transplantation plays a crucial role in the clinical management of patients receiving ABO-incompatible renal transplants. There is no standardized protocol or an external quality assurance program (EQA) currently available for this testing in Australia. The aim of this study was to investigate the diversity of techniques, test platforms and reagents that were currently in use in various laboratories with the aim of developing an EQA. An online survey was sent to the participants enrolled with the Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) to assess their interest in participation in the pilot study. A total of 24 participants who expressed interest were sent the group O plasma, A1 , A2 and B cells to perform ABO titration using their own methods. Participants reported a wide range of titre results, from 8 to 1024 for the anti-A titre using A1 cells, from 2 to 128 for anti-A titre using A2 cells and from neat to 32 for anti-B titre using B cells. There was a wide variation in titre results between and within different technologies. These findings demonstrate the need for an ABO titration EQA. Development of a standard ...Continue Reading

References

Jul 2, 2014·Annals of Laboratory Medicine·Seon Joo KangSae Yun Baik
Jul 16, 2015·Transfusion·Willy A Flegel
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Lohith S BachegowdaBeth H Shaz
May 12, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Eun Jeong KoUNKNOWN Korean Organ Transplantation Registry Study Group
Oct 7, 2017·The American Journal of Case Reports·Deepak Shankar Ray, Sharmila Thukral
Jun 19, 2018·Xenotransplantation·Mayara Garcia de Mattos BarbosaJeffrey L Platt
Aug 2, 2018·Journal of Nephrology·Kristian AssingClaus Bistrup
Aug 21, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Sweta NayakArchisman Mohapatra
Jun 27, 2019·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M HourmantC Garandeau
Jun 30, 2019·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Tariq AliKhalid Almeshari
Sep 16, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Ryoichi MaenosonoKazunari Tanabe
Apr 9, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Prashant PandeyMukesh Kumar Singh

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