Challenges in paper-based fluorogenic optical sensing with smartphones

Nano Convergence
Tiffany-Heather Ulep, Jeong-Yeol Yoon

Abstract

Application of optically superior, tunable fluorescent nanotechnologies have long been demonstrated throughout many chemical and biological sensing applications. Combined with microfluidics technologies, i.e. on lab-on-a-chip platforms, such fluorescent nanotechnologies have often enabled extreme sensitivity, sometimes down to single molecule level. Within recent years there has been a peak interest in translating fluorescent nanotechnology onto paper-based platforms for chemical and biological sensing, as a simple, low-cost, disposable alternative to conventional silicone-based microfluidic substrates. On the other hand, smartphone integration as an optical detection system as well as user interface and data processing component has been widely attempted, serving as a gateway to on-board quantitative processing, enhanced mobility, and interconnectivity with informational networks. Smartphone sensing can be integrated to these paper-based fluorogenic assays towards demonstrating extreme sensitivity as well as ease-of-use and low-cost. However, with these emerging technologies there are always technical limitations that must be addressed; for example, paper's autofluorescence that perturbs fluorogenic sensing; smartphone flash's...Continue Reading

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Dec 12, 2018·Methods and Applications in Fluorescence·Margaret ChernAllison M Dennis
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Nov 19, 2021·Biomedical Microdevices·Vinay KishnaniAnkur Gupta

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Methods Mentioned

BETA
pregnancy test
surface
FRET
Fluorescence
nucleic acid hybridization
chip
biosensors
DNA assay

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