Challenges in retinal circuit regeneration: linking neuronal connectivity to circuit function

Biological & Pharmaceutical Bulletin
Fumitaka Osakada, Masayo Takahashi

Abstract

Tremendous progress has been made in retinal regeneration, as exemplified by successful transplantation of retinal pigment epithelia and photoreceptor cells in the adult retina, as well as by generation of retinal tissue from embryonic stem cells and induced pluripotent cells. However, it remains unknown how new photoreceptors integrate within retinal circuits and contribute to vision restoration. There is a large gap in our understanding, at both the cellular and behavioral levels, of the functional roles of new neurons in the adult retina. This gap largely arises from the lack of appropriate methods for analyzing the organization and function of new neurons at the circuit level. To bridge this gap and understand the functional roles of new neurons in living animals, it will be necessary to identify newly formed connections, correlate them with function, manipulate their activity, and assess the behavioral outcome of these manipulations. Recombinant viral vectors are powerful tools not only for controlling gene expression and reprogramming cells, but also for tracing cell fates and neuronal connectivity, monitoring biological functions, and manipulating the physiological state of a specific cell population. These virus-based a...Continue Reading

References

Jun 16, 1989·Science·M R Capecchi
May 1, 1997·Transplantation Proceedings·D BreninP Iannaccone
Sep 12, 1998·Journal of Virology·H MiyoshiI M Verma
Oct 10, 1998·Journal of Virology·T DullL Naldini
Jun 17, 2000·Science·Y S Rong, K G Golic
Aug 10, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·H MizuguchiT Hayakawa
Aug 31, 2001·Nature Neuroscience·R H Masland
Dec 6, 2001·Nature Reviews. Neuroscience·N Heintz
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Apr 1, 2003·Nature Biotechnology·Frank SchnütgenNorbert B Ghyselinck
Feb 24, 2004·The Journal of Gene Medicine·J C Pagès, Thierry Bru
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Masatoshi HarutaMasayo Takahashi
Sep 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sotaro OotoMasayo Takahashi
Apr 5, 2005·Journal of Neurovirology·Monique Lafon
Aug 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hanako IkedaYoshiki Sasai
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Sep 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason N D KerrFritjof Helmchen
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Deepak A LambaThomas A Reh
Oct 3, 2006·Cloning and Stem Cells·Raymond D LundRobert Lanza
Oct 13, 2006·Nature Reviews. Neuroscience·Amir Rattner, Jeremy Nathans
Nov 10, 2006·Nature·R E MacLarenR R Ali
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja
Dec 21, 2006·Nature Methods·Ian R WickershamEdward M Callaway
Jan 18, 2007·PloS One·Christopher S Raymond, Philippe Soriano

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Citations

Jan 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumitaka Osakada
Aug 11, 2015·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Fumitaka Osakada
Jun 20, 2017·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masanari Onda, Fumitaka Osakada

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