Challenges in the Early Infant HIV Diagnosis and Treatment Cascade.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Lynne M MofensonEmma Sacks

Abstract

The first step in improving morbidity and mortality among children living with HIV is the timely and early identification of HIV infection, which must be followed by rapid engagement in care and provision of antiretroviral therapy. However, in 2018, only 59% of HIV-exposed infants received an infant nucleic acid diagnostic test by age 2 months and only 54% of children living with HIV received treatment. Because infant diagnosis requires molecular techniques to detect viral nucleic acid, programs for early diagnosis of infection in infants are more complex than those in adults and often require coordination and management of multiple health facilities as well as logistic, financial, and human resource challenges. This article will discuss challenges at each step in the early infant diagnosis cascade and innovations that may help overcome these challenges.

References

Oct 7, 2004·Lancet·Marie-Louise NewellUNKNOWN Ghent International AIDS Society (IAS) Working Group on HIV Infection in Women and Children
Nov 21, 2008·The New England Journal of Medicine·Avy ViolariUNKNOWN CHER Study Team
Jun 23, 2010·BMC Pediatrics·Harriet Nuwagaba-BiribonwohaElaine J Abrams
Dec 24, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Leigh F JohnsonGayle G Sherman
Sep 6, 2012·AIDS·Celina WettsteinUNKNOWN IeDEA Southern Africa Collaboration
Nov 24, 2016·MMWR. Morbidity and Mortality Weekly Report·Karidia DialloJohn Nkengasong
Jul 12, 2017·Public Health Action·Rashida A Ferrand
Mar 8, 2018·The Journal of Infectious Diseases·Kerry A ThomsonUNKNOWN Partners in Prevention HSV/HIV Transmission Study and Partners PrEP Study Teams
Mar 12, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hui ChenPing Wang
Apr 17, 2019·The Lancet. HIV·Mark F Cotton, Helena Rabie
Aug 2, 2019·AIDS Patient Care and STDs·Kathy GogginSarah Finocchario-Kessler
Nov 30, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Zameer MohamedMaud Lemoine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
M BouraimaD K Ekouevi
© 2022 Meta ULC. All rights reserved