PMID: 15330122Aug 28, 2004Paper

Challenges in the search for an HIV vaccine

European Journal of Epidemiology
Angelique A C LemckertDan H Barouch

Abstract

Considerable progress has been made over the past several years in the development of an HIV vaccine. As a result, a growing number of vaccine modalities are being investigated in pre-clinical and phase I/II clinical trials. However, a number of major scientific challenges still remain. It is widely believed that the ideal vaccine should elicit both neutralizing antibodies and cytotoxic T lymphocytes (CTL) against diverse isolates of HIV, but the precise correlates of immunity have not been defined. Recombinant live vector-based vaccines and plasmid DNA vaccines have been shown to induce CTL, either alone or in combination, and these CTL-based vaccines have shown partial protective efficacy in nonhuman primates challenge studies. An immunogen that elicits broadly reactive neutralizing antibodies, however, has yet to be developed.

Citations

Jan 11, 2007·AIDS Research and Human Retroviruses·Matthew E FalagasElpidoforos S Soteriades
Mar 10, 2009·European Journal of Public Health·Truong-Minh PhamTakesumi Yoshimura
Mar 14, 2013·BioMed Research International·Maria Cecilia Garibaldi MarcondesHoward Fox
Dec 2, 2006·American Journal of Public Health·Cynthia M LylesUNKNOWN HIV/AIDS Prevention Research Synthesis Team
Apr 2, 2008·Expert Review of Vaccines·Jeremy WalesMarc Feldmann
Jul 26, 2011·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Xinguang ChenUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions

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