Challenges of clinical translation in nanomedicine: A qualitative study

Nanomedicine : Nanotechnology, Biology, and Medicine
Priya SatalkarDavid Shaw

Abstract

Clinical translation of breakthroughs in nanotechnology and nanomedicine is expected to significantly improve diagnostic tools and therapeutic modalities for various diseases. This will not only improve human health and well-being, but is also likely to reduce health care costs in the long run. However, clinical translation is a long, arduous, resource intensive process that requires priority setting, resource mobilization, successful national and international collaboration, and effective coordination between key stakeholders. The aim of this paper is to describe various challenges faced by the stakeholders involved in translational nanomedicine while planning and conducting first in human clinical trials. We draw on insights obtained from 46 in-depth qualitative interviews with key stakeholders from Europe and North America. Translational research is a crucial step in bringing basic research into clinical reality. This is particularly important in a new field like nanomedicine. Clinical translation is a long and resource intensive process with difficulties along the way. In this article, the authors looked at the challenges faced by various parties in order to help identify ways to overcome these challenges.

References

Jun 22, 2001·Journal of Medical Ethics·J Savulescu
Jan 12, 2008·Annual Review of Medicine·Janet Woodcock, Raymond Woosley
Apr 22, 2009·Clinical Pharmacology and Therapeutics·M FerrariW R Sanhai
Nov 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pakatip RuenraroengsakAlexander T Florence
Nov 26, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Ioannis S Vizirianakis
Dec 15, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Brian C Drolet, Nancy M Lorenzi
May 7, 2011·Accounts of Chemical Research·Twan LammersFabian Kiessling
Oct 7, 2011·Molecular Pharmaceutics·Ruth Duncan, Rogerio Gaspar
Oct 19, 2011·Accounts of Chemical Research·Xiaoyuan ChenJinwoo Cheon
Mar 13, 2012·The AAPS Journal·Neil Desai
Mar 14, 2012·Trends in Pharmacological Sciences·David J Adams
Jun 7, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William C ZamboniPiotr Grodzinski
Oct 16, 2012·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Richard S Saver
Dec 25, 2012·Regenerative Medicine·Sophie L NiemansburgAnnelien L Bredenoord
Jan 5, 2013·Kennedy Institute of Ethics Journal·Audrey R Chapman, Courtney C Scala
Mar 15, 2013·International Journal of Pharmaceutics·Twan Lammers
Aug 15, 2013·Cancer Letters·Daniel Rosenblum, Dan Peer
Mar 29, 2014·Annals of the New York Academy of Sciences·Sally TinkleNeil Desai
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Bruce AlbertsHarold Varmus
May 6, 2014·Expert Opinion on Biological Therapy·Doris A TaylorPaolo Macchiarini
Oct 14, 2014·Advanced Drug Delivery Reviews·Sina EetezadiChristine Allen
Jan 28, 2015·Lancet·Alberto GabizonPiotr Grodzinski
Feb 20, 2015·Nanomedicine·Cornelle W NoorlanderRobert E Geertsma
Mar 1, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Mike A W EatonOlivier M A Fontaine
May 26, 2015·Parkinsonism & Related Disorders·Inmaculada de Melo-MartínClaire Henchcliffe
Jun 9, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Margarethe Hofmann-AmtenbrinkHeinrich Hofmann
Jun 20, 2015·Chemical Reviews·Yuanzeng MinAndrew Z Wang
Sep 16, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Lisa BregoliAdriele Prina-Mello
Sep 17, 2015·Science and Engineering Ethics·Priya SatalkarDavid M Shaw

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Citations

Jun 21, 2017·International Journal of Pharmaceutics·Khalid M El-Say, Hossam S El-Sawy
Aug 6, 2018·Journal of Cellular Physiology·Mohammad MohajeriAmirhossein Sahebkar
Nov 20, 2018·Nanomedicine·Fatemeh FarjadianMichael R Hamblin
Feb 1, 2019·Advanced Materials·Liang YanYuliang Zhao
Aug 6, 2017·The AAPS Journal·Jelena M Janjic, Vijay S Gorantla
Mar 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ruginn CatarataLei Zhai
Jan 4, 2020·Pharmaceutical Research·Christelle ZandanelChristine Vauthier
Jun 8, 2017·Journal of Applied Toxicology : JAT·Hong SuMin Ding
Jun 5, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Iris Coates McCallJudy Illes
Jan 27, 2019·Therapeutic Delivery·Gizem BorAnan Yaghmur
Jun 9, 2019·Drug Discovery Today·Fernando J CabreraCrystal S Shin
Jul 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Barbora TesarovaZbynek Heger
Mar 24, 2021·Nature Nanotechnology·Ameya R KirtaneGiovanni Traverso
May 26, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Philip GrossenJörg Huwyler
Jun 12, 2020·The Journal of Physical Chemistry. B·Belén L BouzoMaría de la Fuente
Feb 5, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Arunendra Saha RayMarie-Christine Daniel
Sep 29, 2020·Journal of Pharmaceutical Innovation·Anaida KadMadhu Khatri

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