Challenges of Post-measurement Histology for the Dielectric Characterisation of Heterogeneous Biological Tissues.

Sensors
Alessandra La GioiaEmily Porter

Abstract

The dielectric properties of biological tissues are typically measured using the open-ended coaxial probe technique, which is based on the assumption that the tissue sample is homogeneous. Therefore, for heterogeneous tissue samples, additional post-measurement sample processing is conducted. Specifically, post-measurement histological analysis may be performed in order to associate the measured dielectric properties with the tissue types present in a heterogeneous sample. Accurate post-measurement histological analysis enables identification of the constituent tissue types that contributed to the measured dielectric properties, and their relative distributions. There is no standard protocol for conducting post-measurement histological analysis, which leads to high numbers of excluded tissue samples and inconsistencies in the resulting reported data for heterogeneous tissues. To this extent, this study examines the post-measurement histological process and the challenges in associating the acquired dielectric properties with the different tissue types present in heterogeneous samples. The results demonstrate that the histological process inevitably alters the morphology of samples, thus introducing errors in the interpretation ...Continue Reading

References

Nov 18, 2006·Physics in Medicine and Biology·C Gabriel, A Peyman
Jun 3, 2009·Tissue Engineering. Part C, Methods·Kaeuis A FarajWilleke F Daamen
Apr 25, 2014·IEEE Transactions on Bio-medical Engineering·Mitko VetaMax A Viergever
Nov 5, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Shailja Chatterjee
Jul 20, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·V LoprestoM Cavagnaro
Jul 12, 2018·IEEE Transactions on Bio-medical Engineering·Declan O'LoughlinM Adnan Elahi

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