Challenges related to the immunogenicity of parenteral recombinant proteins: Underlying mechanisms and new approaches to overcome it

International Reviews of Immunology
Fatemeh FarajiReza Falak

Abstract

Immune response elicited by therapeutic proteins is an important safety and efficacy issue for regulatory agencies, drug manufacturers, clinicians, and patients. Administration of therapeutic proteins can potentially induce the production of anti-drug antibodies or cell-mediated immune responses. At first, it was speculated that the immunogenicity is related to the non-human origin of these proteins. Later on, it was confirmed that the human proteins may also show immunogenicity. In this review article, we will focus on a number of factors, which play crucial roles in the human protein immunogenicity. These factors are related to the patient's status (or intrinsic properties) and molecular characteristics of the therapeutic protein's (or extrinsic properties). Furthermore, we will discuss available in silico, in vitro, and in vivo methods for the prediction of sequences, which may generate an immune response following parenteral administration of these proteins. In summary, nowadays, it is possible for drug manufacturers to evaluate the risk of immunogenicity of therapeutic proteins and implement a management plan to overcome the problems prior to proceeding to human clinical trials.

References

Jan 1, 1992·Annual Review of Immunology·C C Goodnow
Feb 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C M ZwicklD Wierda
Mar 1, 1995·Trends in Biotechnology·Y InadaA Matsushima
Nov 26, 1993·Science·M F BachmannR M Zinkernagel
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A FranzkeJ Atzpodien
Feb 15, 2001·Current Gastroenterology Reports·M L Shiffman
Mar 22, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·A C DykesR C Tait
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L KeechJ McCluskey
May 1, 2001·Nature Biotechnology·J A Kolkman, W P Stemmer
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T G ForsthuberR Weissert
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dipica HaribhaiCalvin B Williams
Mar 21, 2003·Nature·Xiping WeiGeorge M Shaw
Mar 9, 2004·Current Opinion in Plant Biology·Véronique Gomord, Loïc Faye
Jun 3, 2004·Nature Reviews. Immunology·Seung-Yong Seong, Polly Matzinger
Jun 24, 2004·Pharmaceutical Research·Suzanne HermelingWim Jiskoot
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dawn Winsor-HinesPaul D Ponath
Nov 16, 2004·Methods : a Companion to Methods in Enzymology·Anne S De Groot, Jay A Berzofsky
Mar 1, 2005·Analytical Chemistry·Lihua HuangRalph M Riggin
Apr 19, 2005·Journal of Computational Chemistry·Andreas SchreiberUrsula Dietrich
Jun 28, 2005·Nucleic Acids Research·Urmila Kulkarni-KaleA S Kolaskar
Oct 14, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Barthélemy DemeuleTudor Arvinte
Feb 17, 2006·The New England Journal of Medicine·Helen GogasJohn M Kirkwood
Mar 17, 2006·Annals of the Rheumatic Diseases·D MakrygiannakisA I Catrina
Apr 25, 2006·Trends in Biotechnology·Gopi ShankarAnthony Mire-Sluis
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josephine L KlitgaardSøren Bregenholt
Nov 23, 2006·Journal of Pharmaceutical and Biomedical Analysis·Amer Jaber, Matthew Baker
Jan 6, 2007·Journal of Molecular Recognition : JMR·Jason A GreenbaumBjoern Peters
Feb 21, 2007·Expert Opinion on Biological Therapy·Ivo Van WalleIgnace Lasters
Apr 21, 2007·Cellular Immunology·Anne S De GrootWilliam Martin
Oct 30, 2007·Trends in Immunology·Anne S De Groot, David W Scott
Mar 14, 2008·The New England Journal of Medicine·Christine H ChungThomas A E Platts-Mills
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton

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Citations

Feb 27, 2019·International Reviews of Immunology·Himanshu Kumar
May 24, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Mariana Bastos Dos SantosLuis Octavio Regasini
Nov 24, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Diego EnricoBenjamin Besse

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