Challenges to implementing second-dose varicella vaccination during an outbreak in the absence of a routine 2-dose vaccination requirement--Maine, 2006

The Journal of Infectious Diseases
Amy A ParkerKathleen F Gensheimer

Abstract

In June 2005, the Advisory Committee on Immunization Practices (ACIP) recommended administering a second dose of varicella vaccine during outbreaks, supplementing the routine 1-dose requirement. From October 2005 to January 2006, a varicella outbreak occurred in Maine in a highly vaccinated elementary school population. We investigated the outbreak, held a school-based vaccination clinic, and assessed costs in implementing ACIP's outbreak-response recommendation. Parents completed questionnaires and case investigation interviews. Personnel at the Maine Center for Disease Control and Prevention, the school in which the outbreak occurred ("school A"), and physician offices completed economic surveys. Forty-eight cases occurred, with no hospitalizations or deaths. Vaccine effectiveness was 86.6% (95% confidence interval, 82.0%-90.1%). Of 240 eligible students, 132 (55.0%) received second-dose vaccination. Implementing ACIP's outbreak-response recommendation was challenging and cost approximately $26,875. Additionally, the routine 1-dose varicella vaccination policy did not confer adequate population immunity to prevent this outbreak. These findings support ACIP's June 2007 recommendation for a routine 2-dose varicella vaccination ...Continue Reading

References

Sep 1, 1996·Infectious Disease Clinics of North America·M Wharton
Jul 29, 2000·The Journal of Infectious Diseases·P A MeyerM Wharton
Oct 24, 2002·The Pediatric Infectious Disease Journal·Karin GalilJane Seward
Feb 19, 2004·JAMA : the Journal of the American Medical Association·Marietta VázquezEugene D Shapiro
Mar 3, 2004·Pediatrics·Barna D TugwellPaul R Cieslak
Aug 12, 2004·JAMA : the Journal of the American Medical Association·Jane F SewardAisha O Jumaan
Feb 4, 2005·The New England Journal of Medicine·Huong Q NguyenJane F Seward
Jul 5, 2005·Pediatrics·Gustavo H DayanUNKNOWN Iowa Measles Response Team
Mar 1, 2007·Journal of Empirical Research on Human Research Ethics : JERHRE

❮ Previous
Next ❯

Citations

Jan 13, 2010·Clinical Microbiology Reviews·D Scott Schmid, Aisha O Jumaan
Jul 19, 2018·Human Vaccines & Immunotherapeutics·Yuyang XuErping Xu
May 3, 2008·The Journal of Infectious Diseases·Jane F SewardMarietta Vázquez
May 3, 2008·The Journal of Infectious Diseases·Jessica LeungJane F Seward
Jul 14, 2009·The Pediatric Infectious Disease Journal·Philip L GouldSandra Snow
May 3, 2008·The Journal of Infectious Diseases·Dalya GurisJane F Seward
Apr 3, 2012·The Pediatric Infectious Disease Journal·Rulin C HechterHung Fu Tseng
Sep 20, 2010·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·Ben TanUNKNOWN approved by NACI.
Jul 11, 2013·The Pediatric Infectious Disease Journal·Paolo BonanniPeter Wutzler
May 29, 2020·BioMed Research International·Min ZhangRi-Sheng Zha
Oct 14, 2010·Central European Journal of Public Health·Maja Socan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.