Challenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site.

Neuro-oncology
Michelle W MaIman Osman

Abstract

Melanoma brain metastasis that develops as the isolated first visceral site challenges the current paradigm of tumor progression in which brain metastasis is regarded as the final stage. Here we test the hypothesis that melanoma patients who develop brain metastasis as the isolated first visceral site have distinct clinicopathological features at the time of primary melanoma diagnosis. Cutaneous melanoma patients enrolled in 2 prospectively collected databases were studied (Cohort 1: 1972-1982, Cohort 2: 2002-2009). Patients who developed brain metastasis as isolated first visceral site were compared with (1) all other patients, (2) patients who developed visceral metastasis: extracranial only or extracranial and brain, and (3) patients who progressed to other isolated visceral sites first. Two hundred seven of 2280 (9.1%) patients developed brain metastasis (median follow-up, 5.2 y). Seventy-four of 207 (35.7%) brain metastasis patients progressed to brain metastasis as the isolated first visceral site. These patients presented with primaries that were thinner and had no mitosis compared with all other visceral metastasis patients (Fisher's combined P = .02, .05, respectively), and there was a significant difference in America...Continue Reading

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Citations

Apr 5, 2017·Current Treatment Options in Neurology·Anna S Berghoff, Matthias Preusser
Mar 26, 2014·Neurosurgery·Douglas KondziolkaJay S Loeffler
Jan 25, 2020·Journal of the National Cancer Institute·Shirin BajajIman Osman
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