Challenging the neuronal MIBG uptake by pharmacological intervention: effect of a single dose of oral amitriptyline on regional cardiac MIBG uptake

European Journal of Nuclear Medicine and Molecular Imaging
M EstorchJ Narula

Abstract

Imaging with metaiodobenzylguanidine (MIBG) is used for the assessment of neuronal dysfunction in various cardiovascular disorders. Although valuable information is obtained by resting MIBG imaging, it is conceivable that competitive interference with the re-uptake mechanism would exaggerate MIBG defects and might unmask subclinical neuronal dysfunction. Tricyclic antidepressants, such as amitriptyline, have been reported to significantly increase cardiac MIBG washout and inhibit uptake into presynaptic neurons. This study was undertaken to assess whether a single oral dose of amitriptyline could influence cardiac MIBG distribution. Six patients (aged 62-81 years; four males, two females) who had demonstrated a normal cardiac MIBG scan during work-up for movement disorders were studied. The patients underwent a second 123I-MIBG study after oral administration of 25 mg amitriptyline within 1 week. Single-photon emission computed tomography images were acquired at 4 h to assess the regional distribution of MIBG, after generation of polar maps and employing a 20-segment model. Mean percentage of peak activity was calculated for each segment at rest and after amitriptyline administration. After amitriptyline administration, there w...Continue Reading

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Citations

Dec 18, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Peter J Ell, UNKNOWN European Association of Nuclear Medicine
Aug 29, 2012·European Journal of Nuclear Medicine and Molecular Imaging·David TaïebUNKNOWN European Association of Nuclear Medicine
Feb 5, 2010·JACC. Cardiovascular Imaging·Vasken DilsizianJagat Narula
Jun 5, 2014·Psychiatry and Clinical Neurosciences·Katsutoshi YokoyamaKoichi Kaneko
May 16, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arnold F Jacobson, Mark I Travin
Mar 12, 2008·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Wim Van Thuyne, Frans T Delbeke
Jun 17, 2020·Seminars in Nuclear Medicine·Gedaliah FarberBenjamin H Rotstein
Jul 22, 2019·JACC. Cardiovascular Imaging·Jason G E ZeltLisa M Mielniczuk
Jul 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frank M Bengel

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