Chamber exposures of children to mixed ozone, sulfur dioxide, and sulfuric acid

Archives of Environmental Health
W S LinnE L Avol

Abstract

To help assess acute health effects of summer air pollution in the eastern United States, we simulated ambient "acid summer haze" as closely as was practical in a laboratory chamber. We exposed young volunteers who were thought to be sensitive to this pollutant mixture on the basis of previous epidemiologic evidence. Specifically, we exposed 41 subjects aged 9-12 y to mixed ozone (0.10 ppm), sulfur dioxide (0.10 ppm), and 0.6-microm sulfuric acid aerosol (100 +/- 40 microg/m3, mean +/- standard deviation) for 4 h, during which there was intermittent exercise. Fifteen subjects were healthy, and 26 had allergy or mild asthma. The entire group responded nonsignificantly (p > .05) to pollution exposure (relative to clean air), as determined by spirometry, symptoms, and overall discomfort level during exercise. Subjects with allergy/asthma showed a positive association (p = .01) between symptoms and acid dose; in healthy subjects, that association was negative (p = .08). In these chamber-exposure studies, we noted less of an effect than was reported in previous epidemiologic studies of children exposed to ambient "acid summer haze."

References

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Citations

Apr 8, 2004·Environmental Research·Jon-Pierre MichaudDmitry Krupitsky
May 17, 2000·Current Opinion in Pulmonary Medicine·W S Linn, H Gong
Mar 14, 2003·Environmental Health Perspectives·Victor J FeronJob A van Zorge
Sep 10, 2002·Journal of Toxicology. Clinical Toxicology·Monique Mathieu-Nolf
Jul 25, 2015·Pediatric Pulmonology·Fiona C GoldizenLuke D Knibbs
Jun 12, 2012·Regulatory Toxicology and Pharmacology : RTP·Mia K V JohanssonMattias Oberg
Feb 28, 2008·Journal of Occupational and Environmental Medicine·Ephraim I ThallerEdward G Brooks

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