ChAMP: 450k Chip Analysis Methylation Pipeline

Bioinformatics
Tiffany J MorrisStephan Beck

Abstract

The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-throughput DNA methylation analysis. Several methods for normalization and processing of these data have been published recently. Here we present an integrated analysis pipeline offering a choice of the most popular normalization methods while also introducing new methods for calling differentially methylated regions and detecting copy number aberrations. ChAMP is implemented as a Bioconductor package in R. The package and the vignette can be downloaded at bioconductor.org

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Citations

Jul 16, 2014·Metallomics : Integrated Biometal Science·Tomasz K WojdaczKarin Broberg
Sep 30, 2014·Nature Methods·Yassen AssenovChristoph Bock
Mar 13, 2016·Seminars in Oncology·Daoud MeerzamanSharon Ross
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