Chance and necessity in the pleiotropic consequences of adaptation for budding yeast.

Nature Ecology & Evolution
E. R. JerisonSergey Kryazhimskiy

Abstract

Mutations that a population accumulates during evolution in one 'home' environment may cause fitness gains or losses in other environments. Such pleiotropic fitness effects determine the evolutionary fate of the population in variable environments and can lead to ecological specialization. It is unclear how the pleiotropic outcomes of evolution are shaped by the intrinsic randomness of the evolutionary process and by the deterministic variation in selection pressures across environments. Here, to address this question, we evolved 20 replicate populations of the yeast Saccharomyces cerevisiae in 11 laboratory environments and measured their fitness across multiple conditions. We found that evolution led to diverse pleiotropic fitness gains and losses, driven by multiple types of mutations. Approximately 60% of this variation is explained by the home environment of a clone and the most common parallel genetic changes, whereas about 40% is attributed to the stochastic accumulation of mutations whose pleiotropic effects are unpredictable. Although populations are typically specialized to their home environment, generalists also evolved in almost all of the conditions. Our results suggest that the mutations that accumulate during ev...Continue Reading

References

Jan 1, 1992·Annual Review of Microbiology·R B Wickner
Aug 2, 2001·Nature Biotechnology·F StoriciM A Resnick
Aug 8, 2002·FEMS Microbiology Reviews·Manfred J Schmitt, Frank Breinig
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·R Craig MacLeanPaul B Rainey
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shaobin ZhongAntony M Dean
Nov 22, 2005·Genetics·Siobain DuffyChristina L Burch
Dec 1, 1993·Applied and Environmental Microbiology·P VagnoliG Coratza
Feb 21, 2006·Nature Reviews. Microbiology·Manfred J Schmitt, Frank Breinig
Sep 28, 2006·PLoS Genetics·Aleeza C GersteinSarah P Otto
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Albert F Bennett, Richard E Lenski
Oct 19, 2007·Nature Reviews. Genetics·Thomas Mitchell-OldsDavid B Goldstein
Nov 7, 2007·Evolution; International Journal of Organic Evolution·Duncan Greig, Michael Travisano
Jan 19, 2008·Genetics·Gregory I Lang, Andrew W Murray
Feb 7, 2009·Science·Dolph Schluter
Jun 24, 2009·Evolution; International Journal of Organic Evolution·Ming-Chun LeeChristopher J Marx
May 7, 2011·Genetics·Gregory I LangMichael M Desai
May 10, 2011·Trends in Genetics : TIG·Jill T AndersonThomas Mitchell-Olds
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Benjamin H GoodMichael M Desai
Mar 17, 2012·Molecular Ecology·Jill T AndersonThomas Mitchell-Olds
May 4, 2013·Journal of Evolutionary Biology·J-N Jasmin, C Zeyl
Sep 14, 2013·FEMS Yeast Research·Magdalena D PieczynskaRyszard Korona
Oct 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xiao Yi, Antony M Dean
Oct 19, 2013·Nature Reviews. Genetics·Outi SavolainenJuha Merilä
Oct 30, 2013·Nature Reviews. Genetics·Jeffrey E Barrick, Richard E Lenski
Dec 5, 2013·Evolution; International Journal of Organic Evolution·Ryan T HietpasDaniel N A Bolon
Dec 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jon ÅgrenaDouglas W Schemske
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alejandra Rodríguez-VerdugoAlbert F Bennett
Sep 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Seungsoo KimRoy Kishony
Dec 3, 2014·Trends in Ecology & Evolution·Peter Tiffin, Jeffrey Ross-Ibarra
Dec 4, 2014·Current Opinion in Virology·Stéphanie BedhommeSantiago F Elena
Mar 4, 2015·Nature·Anna M SelmeckiDavid Pellman
May 23, 2015·PloS One·Michael BaymRoy Kishony
Nov 7, 2015·PLoS Genetics·Karin VoordeckersKevin J Verstrepen
Dec 15, 2015·The American Naturalist·Alana SchickRees Kassen
Sep 10, 2016·Molecular Ecology·Santiago F Elena
Aug 23, 2017·ELife·Elizabeth R JerisonMichael M Desai

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Citations

Jul 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sandeep VenkataramBetul Kacar
Jan 13, 2021·Nature Ecology & Evolution·Duhita G SantMichael J McDonald
Apr 29, 2021·Proceedings. Biological Sciences·Lisa FreundGregory J Velicer
Jun 17, 2021·Proceedings. Biological Sciences·Nathan G WalworthNaomi M Levine
Jun 27, 2021·Science Advances·Felix H LamGregory Stephanopoulos

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Methods Mentioned

BETA
flow cytometry
electrophoresis
Hi-seq

Software Mentioned

learn
scikit
Python

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