PMID: 6405281May 5, 1983Paper

Chance, necessity and antibody gene dynamics

Nature
C Coleclough

Abstract

Early in their development B lymphocytes commit themselves to the expression of only one immunoglobulin light-chain gene and only one heavy-chain gene out of the large numbers of available loci. Here I shall present the view that the initial selection of loci for expression is made by chance, whereas the exclusion of other loci from expression is a necessity imposed by the physiology of lymphocyte development.

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Jan 1, 1984·Immunogenetics·D M GibsonB J Mathieson
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