PMID: 108249Apr 1, 1979

Change from homo- to heterolactic fermentation by Streptococcus lactis resulting from glucose limitation in anaerobic chemostat cultures

Journal of Bacteriology
T D ThomasV M Longyear


Lactic streptococci, classically regarded as homolactic fermenters of glucose and lactose, became heterolactic when grown with limiting carbohydrate concentrations in a chemostat. At high dilution rates (D) with excess glucose present, about 95% of the fermented sugar was converted to l-lactate. However, as D was lowered and glucose became limiting, five of the six strains tested changed to a heterolactic fermentation such that at D = 0.1 h(-1) as little as 1% of the glucose was converted to l-lactate. The products formed after this phenotypic change in fermentation pattern were formate, acetate, and ethanol. The level of lactate dehydrogenase, which is dependent upon ketohexose diphosphate for activity, decreased as fermentation became heterolactic with Streptococcus lactis ML(3). Transfer of heterolactic cells from the chemostat to buffer containing glucose resulted in the nongrowing cells converting nearly 80% of the glucose to l-lactate, indicating that fine control of enzyme activity is an important factor in the fermentation change. These nongrowing cells metabolizing glucose had elevated (ca. twofold) intracellular fructose 1,6-diphosphate concentrations ([FDP](in)) compared with those in the glucose-limited heterolactic...Continue Reading


Sep 1, 1990·FEMS Microbiology Reviews·S E Lindgren, W J Dobrogosz
Jan 1, 1990·Critical Reviews in Food Science and Nutrition·P F FoxT M Cogan
Jul 10, 2007·Journal of Bacteriology·Christian SolemPeter Ruhdal Jensen
Jun 26, 2007·Journal of Bacteriology·Stacie A Brown, Marvin Whiteley
May 14, 2016·Applied Microbiology and Biotechnology·Way Cern KhorKorneel Rabaey
Jun 5, 2019·Molecular Biotechnology·Narisetty VivekParameswaran Binod
Jan 2, 1985·European Journal of Biochemistry·M J HardmanG G Pritchard
Aug 1, 1983·Archives of Microbiology·D Caspari, J M Macy
Jan 1, 1989·Critical Reviews in Microbiology·W N KoningsA J Driessen
Sep 1, 1983·Antonie van Leeuwenhoek·W N Konings, R Otto
Feb 20, 2003·Journal of Bacteriology·Christian SolemPeter Ruhdal Jensen
Dec 16, 2004·Applied Microbiology and Biotechnology·Barrie Fong ChongLars K Nielsen
Jul 16, 2009·Antonie van Leeuwenhoek·Petri-Jaan LahtveeRaivo Vilu
Oct 25, 2011·Applied and Environmental Microbiology·Anisha GoelDouwe Molenaar
Mar 19, 2014·PloS One·Siu Hung Joshua ChanPeter Ruhdal Jensen
Aug 1, 1996·Letters in Applied Microbiology·A F Kelly, R A Patchett
Dec 1, 1981·Veterinary Research Communications·G H Counotte, R A Prins
May 5, 1998·Journal of Dairy Science·E Fernández-GarcíaS Traylor
Sep 1, 1986·The Journal of Applied Bacteriology·H J Finlayson
Jun 19, 2001·Biotechnology and Bioengineering·C R MelchiorsenJ Villadsen
Aug 30, 2002·Applied and Environmental Microbiology·Brian J KoebmannPeter Ruhdal Jensen
Nov 13, 2004·Proteomics·Johan PalmfeldtPeter James
Apr 7, 2004·Applied and Environmental Microbiology·Roel Van der MeulenLuc De Vuyst
Oct 25, 2007·Journal of Molecular Microbiology and Biotechnology·Karine RoyMichel-Yves Mistou
Apr 23, 2010·Applied Biochemistry and Biotechnology·Aline Mara Barbosa Pires, Maria Helena A Santana
Mar 26, 2015·Applied Microbiology and Biotechnology·Javier Ferrer ValenzuelaRodrigo Bórquez Yáñez
Oct 1, 1996·Antonie van Leeuwenhoek·M Cocaign-BousquetN D Lindley
Aug 12, 2000·Journal of Bacteriology·C R MelchiorsenJ Arnau
Sep 4, 2004·Applied and Environmental Microbiology·Johan PalmfeldtEd W J Van Niel
Nov 6, 2009·Molecular Systems Biology·Douwe MolenaarBas Teusink
Aug 20, 1989·Biotechnology and Bioengineering·N C Major, A T Bull
Aug 14, 2002·Journal of Applied Microbiology·J MetaxopoulosE H Drosinos
Apr 25, 2007·Critical Reviews in Microbiology·Magdalena Kowalczyk, Jacek Bardowski
Sep 1, 2012·Biotechnology Letters·Anisha GoelBas Teusink
May 1, 1993·World Journal of Microbiology & Biotechnology·S P SinghP J Rogers
Feb 14, 2009·Applied Microbiology and Biotechnology·Felix Lopez de Felipe, Philippe Gaudu
Dec 8, 2015·Applied and Environmental Microbiology·Dorothee TegtmeierAndreas Brune
Feb 9, 2020·Biotechnology and Bioengineering·Julius Laurens RomboutsMark Cornelis Maria van Loosdrecht
May 26, 2001·Applied and Environmental Microbiology·N B JensenJ Villadsen
Aug 7, 2010·Journal of Biomedicine & Biotechnology·Nelson Pérez GuerraLorenzo Pastrana
Mar 7, 2013·Environmental Microbiology·Onur ErcanMichiel Kleerebezem

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