Change in biomarkers of type-2 inflammation following severe exacerbations of asthma

Thorax
Ruth SempriniIrene Braithwaite

Abstract

We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×109/L, p<0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p<0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p<0.001). A delay of 4-8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma. TRIAL REGISTRATION NUMBER: Post-results; The Australia New Zealand Trial Registry, >ACTRN12614000443695.

References

Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Aug 5, 2011·The New England Journal of Medicine·Jonathan CorrenJohn G Matthews
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Nicola A HananiaWilliam Busse
Sep 10, 2014·The New England Journal of Medicine·Hector G OrtegaUNKNOWN MENSA Investigators
Dec 31, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RobinsonP Nair

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