Change in bladder contractility associated with bladder overactivity in rats with cerebral infarction

The Journal of Urology
O YokoyamaM Namiki

Abstract

To evaluate the contractile properties of overactive bladder from rats in the chronic stage of experimental cerebral infarction. Cystometry was performed in conscious male S-D rats after inducing occlusion of the left middle cerebral artery. Bladder muscle strips were evaluated for force development in response to field stimulation, acetylcholine and KCl. By measuring the contractile response to field stimulation after adding atropine and alpha,beta-methylene-ATP, contributions of cholinergic and purinergic transmission were determined. Bladder capacity of cerebral-infarcted rats was <50% of the capacity of sham-operated rats and significantly less than that of sham-operated rats even 4 months after surgery. There was no significant difference in bladder weight between sham-operated rats and cerebral-infarcted rats. No differences in the contractile response of detrusor strips to field stimulation and acetylcholine, or in the relative contribution of cholinergic and purinergic transmission to the contractile response, were observed over time or between strips from sham-operated rats and cerebral-infarcted rats. KCl induced significantly less contraction in strips from 4 month infarcted rats than in strips from 4 month sham-oper...Continue Reading

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Citations

Nov 24, 1999·Urology·M YoshiyamaM B Chancellor
Sep 23, 2003·European Urology·Rikard PehrsonKarl Erik Andersson
Feb 28, 2002·Clinical Obstetrics and Gynecology·Roger P Goldberg, Peter K Sand
Jul 11, 2006·Urologia Internationalis·Satoshi YotsuyanagiMikio Namiki
Apr 7, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Gen YamamotoKazuo Takahama
Feb 18, 2016·International Urogynecology Journal·Emilio SaccoDiego Currò
Oct 20, 2010·The Urologic Clinics of North America·Seong Jin JeongSeung-June Oh
Feb 3, 2007·Urology·Hwancheol SonJae-Seung Paick
Sep 12, 2012·Neurourology and Urodynamics·Joseph J KellerHerng-Ching Lin
Feb 13, 2003·The Urologic Clinics of North America·Mike B Siroky
Sep 24, 1999·The Journal of Urology·Y NakamuraH Kontani
Dec 12, 2002·Scandinavian Journal of Urology and Nephrology. Supplementum·Osamu YokoyamaMikio Namiki

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