Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative.

Annals of the Rheumatic Diseases
D J HunterOAI Investigators

Abstract

The performance characteristics of hyaline articular cartilage measurement on magnetic resonance imaging (MRI) need to be accurately delineated before widespread application of this technology. Our objective was to assess the rate of natural disease progression of cartilage morphometry measures from baseline to 1 year in knees with osteoarthritis (OA) from a subset of participants from the Osteoarthritis Initiative (OAI). Subjects included for this exploratory analysis are a subset of the approximately 4700 participants in the OAI Study. Bilateral radiographs and 3T MRI (Siemans Trio) of the knees and clinical data were obtained at baseline and annually in all participants. 160 subjects from the OAI Progression subcohort all of whom had both frequent symptoms and, in the same knee, radiographic OA based on a screening reading done at the OAI clinics were eligible for this exploratory analysis. One knee from each subject was selected for analysis. 150 participants were included. Using sagittal 3D DESSwe (double echo, steady-state sequence with water excitation) MR images from the baseline and 12 follow-up month visit, a segmentation algorithm was applied to the cartilage plates of the index knee to compute the cartilage volume, ...Continue Reading

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Citations

May 8, 2010·Skeletal Radiology·Erika SchneiderTimothy E McAlindon
Jan 22, 2011·Rheumatology International·Verena SteinDavid J Hunter
Aug 19, 2010·Nature Reviews. Rheumatology·Richard M Aspden
Nov 17, 2010·Nature Reviews. Rheumatology·David J Hunter
Jul 12, 2012·Nature Reviews. Rheumatology·Felix EcksteinMichael C Nevitt
Nov 3, 2011·Arthritis·Felix Eckstein, Wolfgang Wirth
Feb 1, 2009·Therapeutic Advances in Musculoskeletal Disease·David J Hunter
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Yuanyuan WangFlavia M Cicuttini
Aug 4, 2012·Therapeutic Advances in Musculoskeletal Disease·Tuhina Neogi
Apr 15, 2014·Annals of the Rheumatic Diseases·Felix EcksteinUNKNOWN OAI investigators
Jul 23, 2011·Radiology·Frank W RoemerAli Guermazi
Jan 24, 2012·Best Practice & Research. Clinical Rheumatology·David J Hunter
May 7, 2011·Magnetic Resonance Imaging·Janet GoldensteinSharmila Majumdar
Nov 26, 2009·Rheumatic Diseases Clinics of North America·David J Hunter
Nov 26, 2009·Rheumatic Diseases Clinics of North America·Frank W RoemerAli Guermazi
Jul 28, 2009·Radiologic Clinics of North America·David J Hunter
Jul 28, 2009·Radiologic Clinics of North America·Felix EcksteinFrank W Roemer
Dec 9, 2008·The Medical Clinics of North America·Ali GuermaziFrank W Roemer
Dec 9, 2008·The Medical Clinics of North America·David J Hunter, Marie-Pierre Hellio Le Graverand-Gastineau
Dec 20, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ernesto StaroswieckiBrian A Hargreaves
Apr 13, 2013·Journal of Magnetic Resonance Imaging : JMRI·Megan S CromerShih-Chang Wang
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert J BuckUNKNOWN A9001140 Investigators
Feb 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wolfgang WirthUNKNOWN OAI Investigators
Jul 1, 2010·Arthritis Care & Research·O D BenichouUNKNOWN Osteoarthritis Initiative Investigators
Feb 10, 2012·IEEE Transactions on Bio-medical Engineering·José G Tamez-PeñaSaara Totterman
May 9, 2015·Osteoarthritis and Cartilage·D J HunterG E Gold

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