PMID: 6990468Feb 1, 1980Paper

Change in cellular phenotype from lymphoid to erythroid in a case of ALL

Scandinavian Journal of Haematology
L C AnderssonC G Gahmberg

Abstract

Acute leukaemia was diagnosed in a 3-month-old boy. Initial blood leucocyte count was 97 x 10(9)/1, 92% of the cells were morphologically small lymphoblasts which according to surface marker analysis were of the common ALL (non-T non-B) type. Remission was achieved with initial treatment. During relapse 5 months later a morphologically different leukaemic cell appeared in the bone marrow, blood and liquor. This cell type which dominated during the terminal stage of the disease was larger and had an abundant bosophilic cytoplasm which contained PAS-positive granulae. Sudan, myeloperoxidase and benzidine staining gave negative results. Neither T nor B lymphocyte markers were seen but a strong surface expression of glycophorin A was found by indirect immunofluorescence with specific rabbit anti-glycophorin A antiserum. The cells showed a unique surface glycoprotein pattern. Bone marrow karyotype analysis gave in about 80%: 47,XY,+8,t(4:11) indicating that this blast cell represented a malignant clone. As glycophorin A is expressed exclusively on erythroid cells and their precursors, this finding indicates a change from a 'lymphoid' to an erythroid phenotype of the leukaemic cells during the course of the disease.

References

Mar 1, 1976·The Journal of Cell Biology·C G GahmbergL C Andersson
Jan 25, 1979·Human Genetics·H Van den BergheR Eeckels
Mar 15, 1979·International Journal of Cancer. Journal International Du Cancer·L C AnderssonP Vuopio
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·L C AnderssonP Vuopio
Jan 1, 1976·Annual Review of Biochemistry·V T MarchesiM Tomita
Apr 17, 1975·The New England Journal of Medicine·L Sen, L Borella
May 1, 1975·Clinical Immunology and Immunopathology·M F GreavesT A Lister

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Citations

Nov 1, 1983·Cancer·M H ZarrabiH W Grünwald
Jul 1, 1982·Scandinavian Journal of Haematology·M EkblomL C Andersson
Sep 15, 1981·International Journal of Cancer. Journal International Du Cancer·A SuzukiD M Marcus
Jan 1, 1982·Journal of Cellular Physiology. Supplement·M F Greaves
Dec 1, 1981·British Journal of Haematology·K F BradstockA V Hoffbrand

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