PMID: 16629421Apr 25, 2006Paper

Change in clinician-assessed measures of multiple sclerosis and subject-reported quality of life: results from the IMPACT study

Multiple Sclerosis : Clinical and Laboratory Research
Deborah M MillerM L Baier

Abstract

The IMPACT study demonstrated the benefit of interferon beta-1a (IFNbeta-1a, Avonex) two-year change in disability measured by the Multiple Sclerosis Functional Composite (MSFC) in secondary progressive multiple sclerosis (SP-MS) and health-related quality of life (HRQoL) measured by the Multiple Sclerosis Quality of Life Inventory (MSQLI). The IMPACT data permit a detailed assessment of the relation between clinical and self-reported measures. IMPACT was an international randomized, double-blind, placebo-controlled trial of SP-MS patients. As the MSQLI is only in English, this report includes US and Canadian subjects. Subjects were randomized to weekly intramuscular (im) injections of INbeta-1a (60 microg) or placebo for 24 months. At baseline and follow-up, MSQLI correlations were generally stronger with the EDSS than with the MSQLI, MSFC but comparable with MSFC components. Combining the two groups, MSQLI changes for those in the best and worst MSFC change quartiles demonstrated a statistical difference for six of the 11 MSQLI scales. Linear regression demonstrated that EDSS change from baseline to month-24 scores was correlated with change in two MSQLI components. These data support the appropriateness of using the MSQLI wi...Continue Reading

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Citations

Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·R A RudickA W Sandrock
Feb 23, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A M PascualB Casanova
Jan 11, 2011·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Deborah M MillerRichard A Rudick
Oct 1, 2013·The Patient·Christine G KohnCraig I Coleman
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Loredana La MantiaGraziella Filippini

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