Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort

Archives of Internal Medicine
A M KanayaKristine Yaffe

Abstract

A few studies have examined change in cognitive performance by diabetes status with disparate results. We examined the 4-year change in cognitive performance among older adults according to glucose tolerance status. Three cognitive tests (Mini-Mental State Examination, Verbal Fluency [VF] test, and Trail-Making Test B) were measured 4 years apart in 999 white men and women aged 42 to 89 years, who were enrolled in the Rancho Bernardo Study. Participants were classified with normal (NGT), impaired (IGT) or diabetic glucose tolerance. Sex-specific linear regression models adjusted for age, education, depression score, apolipoprotein E epsilon4 allele, and current estrogen use. We checked for mediation by further adjusting for total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels; blood pressure; glycohemoglobin level; and microalbuminuria, retinopathy, stroke, or coronary heart disease. At baseline, mean cognitive function scores did not differ between glucose tolerance groups. Women with diabetes mellitus had a 4-fold increased risk of a major cognitive decline on the VF test after 4 years compared with nondiabetic women. After multivariate adjustment, VF test score...Continue Reading

Citations

Mar 22, 2014·Journal of Proteome Research·Gereon PoschmannKai Stühler
Sep 2, 2006·Neurological Research·Christine Bergmann, Mary Sano
Nov 3, 2009·Diabetologia·E van den BergUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Dec 15, 2012·Aging Clinical and Experimental Research·Isabelle RouchJean-Claude Barthélémy
Jan 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaohan XuGuoqing Tian
Aug 3, 2006·Journal of General Internal Medicine·Rebecca L SudoreDean Schillinger
Jan 25, 2005·Current Diabetes Reports·Lenore J Launer
Apr 26, 2008·Endocrine Reviews·Christopher T Kodl, Elizabeth R Seaquist
Jan 12, 2010·American Journal of Epidemiology·Simerjot K JassalElizabeth Barrett-Connor
Feb 5, 2010·Dementia and Geriatric Cognitive Disorders·Ramit Ravona-SpringerMichal Schnaider Beeri
Jul 16, 2011·Dementia and Geriatric Cognitive Disorders·D ChengJ A Luchsinger
Oct 19, 2011·Neuroepidemiology·Julio R VieiraClinton B Wright
Jan 13, 2012·Journal of Negative Results in Biomedicine·Hui-Chi ChengYen-Ching Chen
Jun 20, 2012·Archives of Neurology·Kristine YaffeTamara B Harris
Oct 9, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Angela M AbbatecolaGiuseppe Paolisso
Sep 4, 2007·Current Neurology and Neuroscience Reports·Rachel A Whitmer
Dec 8, 2006·Diabetologia·K S KrabbeB K Pedersen
Aug 28, 2013·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Atsushi ArakiHideki Ito
Nov 17, 2007·Aging Clinical and Experimental Research·Anna DahlSven E Nilsson
Mar 9, 2010·Journal of Clinical and Experimental Neuropsychology·Claude MessierAlain Desrochers
Sep 10, 2008·Epidemiologic Reviews·Nicola ColeyAlain Grand
Mar 8, 2006·Journal of the International Neuropsychological Society : JINS·G M S NysE H F De Haan
Apr 4, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J-L FuhS-R Lu
Jun 11, 2015·International Journal of Endocrinology·S W SetoD Chang
Aug 26, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shyam SeetharamanNancy L Pedersen
Aug 6, 2014·Diabetes Care·Gilad TwigTali Cukierman-Yaffe
Sep 28, 2006·Diabetes Care·Esther S C KorfLenore J Launer
Jul 25, 2008·Diabetes Care·David G BruceTimothy M E Davis
Mar 29, 2006·Diabetes·Sanne M ManschotUNKNOWN Utrecht Diabetic Encephalopathy Study Group
May 22, 2016·Diabetes Care·Rachel NatovichTali Cukierman-Yaffe
Mar 10, 2009·Journal of the Neurological Sciences·A M TiehuisUNKNOWN SMART Study Group
Sep 17, 2016·Journal of Alzheimer's Disease : JAD·Greg KennedyAndrew Pipingas
Mar 10, 2017·Expert Review of Clinical Pharmacology·Sherifa A Hamed
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Mar 21, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P Di BonitoB Capaldo
Dec 6, 2016·Journal of the American Geriatrics Society·Christiane ReitzJosé A Luchsinger
Jan 15, 2017·Epilepsy & Behavior : E&B·Nadia HafiziMohammad Javad Hosseinzadeh-Attar
Jan 8, 2014·Journal of Geriatric Psychiatry and Neurology·John P RyanCaterina Rosano
Aug 2, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Karri SilventoinenFinn Rasmussen
Apr 3, 2010·American Journal of Alzheimer's Disease and Other Dementias·Eliyahu Hayim MizrahiAbraham Adunsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.