Change in cognitive functioning following acute antidepressant treatment in late-life depression.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Michelle E CulangSteven P Roose

Abstract

Selective Serotonin Reuptake Inhibitors (SSRIs) are the most commonly prescribed medications for geriatric depression. The association of late-life depression and cognitive impairment has been well documented. However, there have been few placebo-controlled trials examining the impact of SSRIs on cognitive functioning. Prepost neuropsychological (NP) data collected as part of an 8-week, double-blind, placebo-controlled trial of citalopram in depressed patients aged 75 years and older were used to examine change in cognitive functioning. University-affiliated outpatient psychiatry clinics. One hundred seventy-four community-dwelling men and women aged 75 years or older with nonpsychotic unipolar depression. NP assessments included mental status (Mini-Mental State Examination), psychomotor speed (Wechsler Adult Intelligence Scale-III Digit Symbol Subtest), reaction time (Choice Reaction Time), visual-spatial skill (Judgment of Line Orientation), executive functioning (Stroop Color/Word Test), and memory (Buschke Selective Reminding Test). Differences in the pattern of change by treatment group depended on responder status. Citalopram nonresponders were the only group to decline on verbal learning and psychomotor speed. Citalopram...Continue Reading

Citations

Sep 16, 2011·International Journal of Geriatric Psychiatry·Michelle E Culang-ReinliebSteven P Roose
Jun 9, 2012·International Journal of Geriatric Psychiatry·Donovan T MaustDavid W Oslin
Jul 26, 2015·The International Journal of Neuropsychopharmacology·Joshua D RosenblatRoger S McIntyre
Nov 13, 2015·International Journal of Geriatric Psychiatry·Gregory H PeltonD P Devanand
Aug 18, 2017·Therapeutic Advances in Chronic Disease·Gopalkumar RakeshAnthony S Zannas
Dec 31, 2010·International Journal of Geriatric Psychiatry·Michelle E Culang-ReinliebJoel R Sneed
Aug 2, 2012·Fundamental & Clinical Pharmacology·Danijela GnjidicBell J S
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Andrea CiprianiCorrado Barbui
Mar 31, 2015·Psychiatric Annals·Sarah Shizuko MorimotoGeorge S Alexopoulos
Aug 5, 2015·Journal of Cancer Survivorship : Research and Practice·John E SchmidtRuth Rechis
Dec 10, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·B CullenD J Smith
Aug 15, 2014·International Journal of Geriatric Psychiatry·Donovan T MaustDavid W Oslin
Feb 24, 2015·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Raymond W LamAtul Khullar
Feb 7, 2015·Annals of the New York Academy of Sciences·Sarah Shizuko MorimotoGeorge S Alexopoulos
Nov 13, 2018·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·John G KeilpBrian A Fallon
Feb 18, 2016·Expert Review of Neurotherapeutics·Radoslaw Magierski, Tomasz Sobow
Oct 25, 2017·Psychiatry and Clinical Neurosciences·Shunsuke TakagiToru Nishikawa
Jun 19, 2020·World Journal of Radiology·Sara N RushiaErnst Garcon
Sep 16, 2014·The Clinical Neuropsychologist·Gro Strømnes DybedalTor Magne Bjølseth
Jul 25, 2021·International Journal of Molecular Sciences·Chien-Yi KuoHsien-Yuan Lane

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