PMID: 11926787Apr 3, 2002Paper

Change in coronary flow reserve on transthoracic Doppler echocardiography after a single high-fat meal in young healthy men

Annals of Internal Medicine
T HozumiShunichi Homma

Abstract

High-fat meals and elevated triglyceride levels are associated with cardiovascular disease. In recent studies of brachial artery vasoactivity, a single high-fat meal reduced endothelial function in young healthy men. It is unknown whether coronary microcirculation is affected after high-fat meals. To evaluate change in coronary flow reserve after a single high-fat meal. Controlled interventional study. University hospitals. 15 young healthy men (mean age [+/-SD], 29 +/- 4 years). Coronary flow reserve was determined by using transthoracic Doppler echocardiography before and after consumption of a high-fat meal in all 15 men and before and after consumption of a low-fat meal in 5 of 15 men. Coronary flow reserve, lipid levels, and hemodynamic characteristics. In all men, triglyceride levels increased significantly from baseline 5 hours after the high-fat meal, from 1.1 mmol/L to 2.8 mmol/L (100 mg/dL to 250 mg/dL) (P < 0.001). Average coronary flow reserve was 4.02 before and 3.30 5 hours after the high-fat meal (decrease, 18% [95% CI, 13% to 23%]). In the 5 men who received both meals, mean coronary flow reserve decreased by 0.79 after the high-fat meal and increased by 0.07 after the low-fat meal (difference, -0.86 [CI, -1.36 ...Continue Reading

Citations

Sep 14, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hiroko NakanishiTakashi Akasaka
Jan 5, 2011·International Journal of Cardiology·Shota FukudaJunichi Yoshikawa
Nov 30, 2004·The American Journal of Cardiology·Eiichi HyodoJunichi Yoshikawa
Nov 25, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Luigi AscioneBernardino Tuccillo
Jul 29, 2004·Metabolism: Clinical and Experimental·Hannu PäiväReijo Laaksonen
May 29, 2004·The American Journal of Cardiology·Kohei FujimotoJunichi Yoshikawa
Sep 2, 2011·The American Journal of Cardiology·Tomoichiro KuboJunichi Yoshikawa
May 28, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patricia Pellikka
Apr 7, 2010·American Heart Journal·Shota FukudaJunichi Yoshikawa
Sep 30, 2003·Diabetes Care·Alain G BertoniFrederick L Brancati
Feb 26, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrick Meimoun, Christophe Tribouilloy
May 10, 2017·Cardiovascular Research·Oana SoropDaphne Merkus
Sep 25, 2003·Human Brain Mapping·Michael D NoseworthySonya Bells
Mar 10, 2004·The British Journal of Nutrition·Peter SandersonJoseph A Vita
Feb 11, 2004·Circulation·Pawel Petkow Dimitrow
May 18, 2012·Circulation. Cardiovascular Imaging·Sheldon E Litwin
Dec 12, 2012·Journal of Cardiovascular Medicine·Gaetano A LanzaUNKNOWN Gruppo di Studio di Fisiopatologia Coronarica e Microcircolazione, Società Italiana di Cardiologia
Nov 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuyoshi TakeiTaishiro Chikamori

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