PMID: 8604962Mar 11, 1996Paper

Change in depression as a precursor of cardiovascular events. SHEP Cooperative Research Group (Systoloc Hypertension in the elderly)

Archives of Internal Medicine
S Wassertheil-SmollerE Schron

Abstract

To determine the relationship between increasing depressive symptoms and cardiovascular events or mortality. Cohort analytic study of data from randomized placebo-controlled double-blind clinical trial of antihypertensive therapy. Depressive symptoms were assessed semi-annually with the Center for Epidemiological Studies-Depression (CES-D) scale during an average follow-up of 4.5 years. Ambulatory patients in 16 clinical centers of the Systolic Hypertension in the Elderly Program. Generally healthy men and women aged 60 years or older randomized to active antihypertensive drug therapy or placebo who were 70% white and 53% women and had follow-up CES-D scores and no outcome events during the first 6 months (N=4367). All-cause mortality, fatal or nonfatal stroke, or myocardial infarction. Baseline depressive symptoms were not related to subsequent events; however, an increase in depression was prognostic. Cox proportional hazards regression analyses with the CES-D scale as a time-dependent variable, controlling for multiple covariates, indicated a 25% increased risk of death per 5-unit increase in the CES-D score (relative risk [RR], 1.25;95% confidence interval [CI], 1.15 to 1.36). The RR for stroke or myocardial infarction was ...Continue Reading

Associated Clinical Trials

Citations

Sep 22, 2011·JAMA : the Journal of the American Medical Association·An PanFrank B Hu
Jun 14, 2013·JAMA Psychiatry·Angelina R SutinAlan B Zonderman
Jan 20, 2011·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·T Fydrich, D Ulsmann
Jun 8, 2002·Current Atherosclerosis Reports·Kenji Narushima, Robert G Robinson
Apr 11, 2003·Current Psychiatry Reports·Wei Jiang, James A Blumenthal
Nov 23, 2011·Current Psychiatry Reports·Nisha Ver HalenPaul L Kimmel
Jul 29, 2004·Current Treatment Options in Neurology·James A. BourgeoisMark E. Servis
Oct 22, 1998·The American Journal of Cardiology·H D SessoD Sparrow
Aug 17, 2002·Biological Psychiatry·Mary Charlson, Janey C Peterson
Feb 13, 2001·Journal of Psychiatric Research·J E PiletzA Halaris
Oct 16, 2002·Journal of Psychosomatic Research·Paolo Cassano, Maurizio Fava
May 16, 2003·General Hospital Psychiatry·Rachel VoellingerFrederic Stiefel
Mar 17, 2004·Journal of Affective Disorders·Alan J ThomasJohn T O'Brien
Mar 10, 2000·Journal of Affective Disorders·R Ramasubbu
Oct 19, 2010·International Psychogeriatrics·Samuel Y WongJean Woo
Sep 6, 2002·Epidemiologia e psichiatria sociale·Hillel W Cohen, James David
Feb 27, 2013·Molecular Psychiatry·W D TaylorG S Alexopoulos
Jun 27, 2012·Nature Reviews. Cardiology·Charles B Nemeroff, Pascal J Goldschmidt-Clermont
Mar 23, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K-H LadwigH-E Wichmann
Apr 11, 2003·The New England Journal of Medicine·Mary E Charlson, O Wayne Isom
Jan 9, 2001·Behavioral Medicine·A AppelsE Schouten
Feb 28, 2001·The Journal of Nervous and Mental Disease·J B SavetskyJ H Samet
Jul 3, 2003·The Journal of Cardiovascular Nursing·Eileen M Stuart-ShorDaniel E Forman
Jun 9, 2007·Current Opinion in Cardiology·Sarah Rivelli, Wei Jiang
Jun 26, 2007·International Journal of Clinical Practice·T N WiseJ Raskin
Jun 20, 1998·BMJ : British Medical Journal·J Hippisley-CoxM Pringle
Dec 8, 2004·Postgraduate Medical Journal·S U ShahW A Littler
Mar 1, 2006·International Journal of Behavioral Medicine·Sarah KnoxMary Whooley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.