Change in functional networks for transitions between states of consciousness during midazolam-induced sedation

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Minji Lee Seong-Whan Lee

Abstract

How brain dynamics change across conscious states, including reliable signatures of the transitions between unconsciousness and consciousness, remains unclear. In this work, we addressed the changes in functional brain networks during self-titrated midazolam sedation using high-density electroencephalography (EEG) in ten subjects. We were particularly interested in the underlying network alterations, identified with graph theory, associated with transitions between states of consciousness. The weighted Phase Lag Index (wPLI) was used as the connectivity estimator between two signals. Based on wPLI, we calculated network properties such as characteristic path length, clustering coefficient, and small-worldness for measuring the integration and segregation of the brain network. We found significant changes in power and wPLI at different levels of consciousness. During unconsciousness, wPLI over the parietal region was higher in the delta band (1-4Hz). The frontal-parietal interaction in the delta band was also stronger during the transition from consciousness to unconsciousness. There was the significant difference of wPLI over the frontal region between consciousness and unconsciousness in the sigma band (12-15Hz). The topologic...Continue Reading

Citations

Apr 6, 2021·Frontiers in Human Neuroscience·Emma R HuelsRichard E Harris

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