PMID: 2106534Feb 1, 1990Paper

Change in haloperidol level due to carbamazepine--a complicating factor in combined medication for schizophrenia

Journal of Clinical Psychopharmacology
E M KahnJ E Alexander

Abstract

Serum haloperidol levels were measured in patients who received haloperidol alone and, subsequently, haloperidol in combination with carbamazepine or lithium carbonate. Haloperidol levels and the level- dose ratios dropped about 50% in patients receiving carbamazepine. They remained the same in most patients receiving lithium carbonate. One patient receiving added carbamazepine experienced worsening of symptoms; this was associated with a drop in serum haloperidol level. Two other patients receiving added carbamazepine showed significant symptom reduction, although they also sustained drops in serum haloperidol levels. It is not clear whether these two individuals benefited from a primary antipsychotic effect of carbamazepine or from reduction of "toxic" haloperidol levels. Serum levels of antipsychotic medication should be monitored carefully when these medications are prescribed in combination with carbamazepine.

Citations

Dec 28, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·R Fukuda
Apr 20, 2000·British Journal of Clinical Pharmacology·J J MiceliA Laurent
Dec 18, 2001·Biological Psychiatry·R R Conley, D L Kelly
Feb 1, 1996·The Australian and New Zealand Journal of Psychiatry·C Pantelis, T R Barnes
Oct 29, 2015·The Cochrane Database of Systematic Reviews·Stefan LeuchtJohn J McGrath
Jan 13, 2004·Clinical Pharmacokinetics·Candace S BrownSamantha F Eichner
Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Frank M C Besag, David Berry
Jul 5, 2019·Expert Opinion on Drug Metabolism & Toxicology·Donatella MarazzitiLiliana Dell'Osso
May 3, 2014·The Cochrane Database of Systematic Reviews·Stefan LeuchtJohn McGrath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Journal of Clinical Psychopharmacology
M W JannC L Bowden
Journal of Clinical Psychopharmacology
J VolavkaP Czobar
Journal of Clinical Psychopharmacology
P CzoborR C Meibach
The Journal of Nervous and Mental Disease
J N HerreraB N Nguyen
© 2021 Meta ULC. All rights reserved