Change in kidney function after unilateral adrenalectomy in patients with primary aldosteronism: identification of risk factors for decreased kidney function

International Urology and Nephrology
Il Young KimHyun Chul Chung

Abstract

Glomerular filtration rate (GFR) has been reported to decrease after unilateral adrenalectomy in patients with primary aldosteronism (PA). The aim of this study was to identify clinical predictors for decreased GFR after adrenalectomy in patients with PA. The records of 187 patients (98 patients with PA and 89 with non-PA adrenal disease) who were followed up for at least 6 months after unilateral adrenalectomy were retrospectively analyzed. Estimated GFR (eGFR) was investigated at 1, 3, and 6 months postoperatively. Preoperative risk factors for eGFR% decline at 1 month ([preoperative eGFR-eGFR at 1 month]/preoperative eGFR × 100) and postoperative CKD development were investigated. The eGFR decreased significantly at 1 month and remained stable in the PA group. However, there were no significant changes in eGFR in the non-PA group over the 6-month period. In the PA group, a high preoperative eGFR and high aldosterone to renin ratio (ARR) were independently associated with eGFR% decline at 1 month. In patients with PA but without preoperative CKD (n = 68), a low preoperative eGFR and high ARR were independent risk factors for developing postoperative CKD. The best preoperative cut-off values of eGFR and ARR for predicting the ...Continue Reading

References

Feb 1, 1977·The Journal of Urology·D N DanforthN Javadpour
Jul 1, 1992·World Journal of Surgery·G FaviaD F D'Amico
Jun 18, 2004·Kidney International·Norman K Hollenberg
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Jean RibsteinAlbert Mimran
Apr 20, 2005·Journal of the American College of Cardiology·Paul MilliezJean-Jacques Mourad
Jun 15, 2006·JAMA : the Journal of the American Medical Association·Leonardo A SechiCristiana Catena
Jun 28, 2006·Hypertension·Gian Paolo RossiUNKNOWN PAPY Study Participants
Dec 13, 2006·Journal of the American College of Cardiology·Gian Paolo RossiUNKNOWN PAPY Study Investigators
Apr 27, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Roberto FogariAmedeo Mugellini
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Cristiana CatenaLeonardo A Sechi
Jan 15, 2009·The Journal of Clinical Endocrinology and Metabolism·Leonardo A SechiCristiana Catena
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 25, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vin-Cent WuUNKNOWN TAIPAI Study Group
Mar 26, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Chin-Chi KuoUNKNOWN Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group)
Feb 22, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C CatenaL A Sechi
Nov 30, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Takanobu UtsumiTomohiko Ichikawa
Jun 16, 2015·International Journal of Endocrinology·Cristiana CatenaLeonardo A Sechi
Dec 14, 2016·Kidney Research and Clinical Practice·Dong-Chan JinJongha Park
Dec 14, 2016·Kidney Research and Clinical Practice·Su Min ParkSang Heon Song

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Citations

Jan 24, 2020·Electrolyte & Blood Pressure : E & BP·Jee Young LeeHae-Ryong Yun
Mar 5, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Wessam OsmanIssa Al Salmi
Sep 1, 2021·Journal of Human Hypertension·Tatsuya HazeUNKNOWN JPAS/JRAS Study Group

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