Change in metabolic parameters and weight in response to risperidone monotherapy in young children with nonpsychotic disorders: a prospective open-label study

Child and Adolescent Mental Health
Burcu Ersoz Alan, S Ebru Cengel Kultur

Abstract

This study investigates changes in metabolic parameters in prepubertal children after 14-16 weeks of treatment with low-dose risperidone. Thirty-one children (mean age 5.46 ± 1.98 years) were treated with risperidone (0.25-1 mg/day; 0.01-0.07 mg/kg/day). Patients were excluded if they were using any medication other than risperidone or were diagnosed with any medical problem in addition to a non-psychotic disorder. Weight (Δ: 2.51 ± 1.94 kg), height (Δ: 0.03 ± 0.04 cm), BMI (Δ: 0.82 ± 1.4), BMI percentile (Δ: 9.72 ± 16.40), BMI z-score (Δ: 0.33 ± 1.03), triglyceride (Δ: 1.50 ± 23.97 mg/dl), very low density lipoprotein (Δ: 2.99 ± 4.76 mg/dl), insulin (Δ: 3.07 ± 3.38 mIU/ml), and leptin (Δ: 3.02 ± 4.69 ng/ml) were significantly increased (p < .05). The metabolic side effects of risperidone must be carefully monitored in prepubertal children.

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Citations

Apr 3, 2014·Journal of Child and Adolescent Psychopharmacology·Mehmet BurcuDaniel J Safer
Jan 26, 2018·Basic & Clinical Pharmacology & Toxicology·Chonlaphat SukasemPenkhae Limsila

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