PMID: 9194104Jun 1, 1997Paper

Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children

The Pediatric Infectious Disease Journal
R CohenP Geslin

Abstract

Acute otitis media is the leading reason for antibiotic prescriptions in childhood. The increase in antibiotic resistance of Streptococcus pneumoniae is generally attributed to the extensive use of antibiotics and the selective pressure on the bacterial strains of the nasopharyngeal flora. To evaluate the change in nasopharyngeal carriage of S. pneumoniae during antibiotic therapy prescribed for acute otitis media. Between October, 1993, and March, 1994, we conducted a clinical trial comparing cefpodoxime-proxetil and amoxicillin-clavulanate in acute otitis media. From 364 children, 4 months to 4.5 years old, a nasopharyngeal sample was obtained before and after treatment. Antibiotic susceptibility was established by determining minimal inhibitory concentrations by the agar dilution method. Serotype and randomly amplified polymorphic DNA analysis were used to compare pre- and posttreatment S. pneumoniae strains. The risk for a child to carry penicillin-resistant S. pneumoniae (MIC > or = 0.125 mg/l) did not increase after antibiotic treatment: 84 of 364 (23.1%) before, 70 of 364 (19.2%) after. There was a significant decrease of penicillin-susceptible S. pneumoniae carriage, 117 of 364 (32.1%) before treatment compared with 24 ...Continue Reading

References

Jan 1, 1976·Infection·M Majer
Dec 1, 1975·The Journal of Pediatrics·F A LodaF W Denny
Dec 1, 1992·The Journal of Infectious Diseases·M R ReichlerR O Walton
Jun 1, 1992·The Journal of Infectious Diseases·G AnianssonC Svanborg
Aug 1, 1991·The Journal of Infectious Diseases·R HakenbeckC Martin
Jul 1, 1986·The Journal of Infectious Diseases·S M SpinolaJ G Cannon
Jan 1, 1995·Antimicrobial Agents and Chemotherapy·P GehannoP Berche
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·K V Clemons, D A Stevens
Aug 1, 1995·The Journal of Antimicrobial Chemotherapy·H Carsenti-EtesseP Dellamonica
Oct 1, 1995·The Pediatric Infectious Disease Journal·D J BokenC J Harrison
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Brook, A E Gober
Apr 1, 1996·The Pediatric Infectious Disease Journal·P GehannoP Berche

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Citations

May 22, 2002·International Journal of Pediatric Otorhinolaryngology·Turgut KarlidağLevent Oztürk
Aug 15, 2002·International Journal of Pediatric Otorhinolaryngology·R HerruzoL Yébenes
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·A LeibermanD M Fliss
Aug 5, 2000·International Journal of Antimicrobial Agents·E Leibovitz, R Dagan
Apr 4, 2003·International Journal of Antimicrobial Agents·Milan Cizman
Mar 6, 1999·Current Opinion in Microbiology·J B McCormick
Oct 6, 1999·Current Opinion in Microbiology·D Guillemot
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A J Leach
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A SissonG P Rabalais
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E VaronR Cohen
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F GhaffarG H McCracken
Mar 27, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Lipsitch
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas W HennessyJay C Butler
Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George A SyrogiannopoulosNicholas G Beratis
Jan 26, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M TsoliaT Karpathios
Aug 10, 1999·The Pediatric Infectious Disease Journal·F GhaffarG H McCracken
Jan 25, 2005·The Pediatric Infectious Disease Journal·Philip ToltzisJeffrey L Blumer
Jan 17, 2003·Paediatric Drugs·Philippe Ovetchkine, Robert Cohen
Jun 15, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R CohenE Varon
May 3, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C LevyR Cohen
Jan 29, 2011·The Lancet Infectious Diseases·Marina BasarabRichard Pebody
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masatoshi KonnoKimiko Ubukata
May 13, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R CohenF de La Rocque
Jan 30, 2015·Frontiers in Cellular and Infection Microbiology·Yashuan ChaoAnders P Hakansson
May 7, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Carbon
Sep 29, 2006·The Pediatric Infectious Disease Journal·Robert Cohen
Apr 20, 2002·Current Opinion in Infectious Diseases·R CohenP Géhanno

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