Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy.

British Journal of Pharmacology
K TikooA B Gaikwad

Abstract

Curcumin has been used to treat cancer, diabetes and other pathologies. However, little is known regarding its role in altering post-translational modifications of histone H3. A recent report suggests that acute hyperglycaemia induces a global down-regulation of gene expression in human tissues and epigenetic regulation of gene expression could be a novel mechanism underlying the pathological processes of hyperglycaemia. The present study was undertaken to examine changes in histone modification by curcumin treatment which prevents development of type I diabetic nephropathy. Male Sprague-Dawley rats were rendered diabetic using a single dose of streptozotocin (55 mg kg(-1), i.p.). Diabetic nephropathy was assessed by measurements of blood urea nitrogen, albumin and creatinine levels. Post-translational modifications of histone H3, heat shock protein-27 (HSP-27) and mitogen-activated protein (MAP) kinase p38 expression were examined by western blotting. Treatment of diabetic rats with curcumin significantly decreased blood urea nitrogen and creatinine and increased albumin; variables associated with the development of diabetic nephropathy. There were also increased levels of HSP-27 and MAP kinase (p38) in diabetic kidney. Howeve...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jun 1, 1997·Biochemical and Molecular Medicine·W ZhangN H Ansari
Jan 22, 1998·Free Radical Biology & Medicine·H H CohlyA K Salahudeen
Apr 30, 1998·Molecular and Cellular Biochemistry·P Suresh Babu, K Srinivasan
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y WeiC D Allis
Sep 12, 1998·The Journal of Biological Chemistry·M J HendzelJ P Th'ng
Jan 23, 1999·The Journal of Clinical Investigation·M IgarashiG L King
Feb 29, 2000·British Journal of Pharmacology·N VenkatesanV Arumugam
Jan 3, 2001·Kidney International·M C Iglesias-De La CruzD Rodríguez-Puyol
Mar 16, 2002·IUBMB Life·A P Arrigo
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Hisashi MakinoKazuwa Nakao
Jul 26, 2002·Brain Research·Zhen-Guo LiAnders A F Sima
Jan 7, 2003·Genes & Development·Mariano Labrador, Victor G Corces
Mar 29, 2003·Diabetes Care·Peter HovindHans-Henrik Parving
Apr 3, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David A AllenMuhammad M Yaqoob
May 6, 2004·Molecular and Cellular Biochemistry·Dinender KumarKevin D Burns
Jul 1, 2004·American Journal of Physiology. Renal Physiology·Jing DongTerrence J Monks
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Matthew D BreyerUNKNOWN AMDCC
Jan 15, 2005·Methods : a Companion to Methods in Enzymology·André-Patrick ArrigoCarole Kretz-remy
Mar 30, 2005·Biochemical Pharmacology·Jiuhong KangYuntao Zhang
Jun 24, 2005·Transplantation·Arjang DjamaliBryan Becker
Sep 20, 2005·The Journal of Nutritional Biochemistry·David A AllenSteven M Harwood
Apr 6, 2006·European Journal of Pharmacology·Sameer SharmaKanwaljit Chopra
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Sameer SharmaKanwaljit Chopra

❮ Previous
Next ❯

Citations

Sep 5, 2013·Environmental Toxicology and Pharmacology·Parveen KumarBabul Bezbaruah
Apr 29, 2009·Expert Reviews in Molecular Medicine·Amber Paratore Sanchez, Kumar Sharma
Jan 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sufyan G SayyedHans-Joachim Anders
May 22, 2013·Journal of Molecular Endocrinology·Chanchal Gupta, Kulbhushan Tikoo
Oct 25, 2011·Epigenomics·Tabitha M Hardy, Trygve O Tollefsbol
Aug 2, 2013·International Journal of Biological Sciences·Yan-Ling WuWen Zhang
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Wei ZhangJun-Li Liu
Jan 8, 2015·Frontiers in Genetics·Theresa Mau, Raymond Yung
Jul 6, 2016·Journal of Diabetes Research·Xiaoxia LiGuangdong Sun
Nov 7, 2012·Molecular and Cellular Endocrinology·Juan HuangHeqing Huang
Dec 22, 2016·Chinese Journal of Integrative Medicine·Xue-Qing Hu, Shi-Bing Su
Mar 20, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Radko KomersKarol Bomsztyk
Mar 1, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Ashish K RehniKulbhushan Tikoo
Aug 30, 2011·Apoptosis : an International Journal on Programmed Cell Death·Ujwal Mukund MahajanKulbhushan Tikoo
Jan 25, 2011·Clinical Epigenetics·Syed M MeeranTrygve O Tollefsbol
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Sayaka MitoYoshifusa Aizawa
Jan 3, 2013·BioFactors·Adeeb ShehzadYoung Sup Lee
May 18, 2020·Diabetes/metabolism Research and Reviews·Ehsan DehdashtianAzam Hosseinzadeh
Sep 24, 2015·Molecular Nutrition & Food Research·Xiao-Qin DingLing-Dong Kong
Jan 11, 2013·Physiological Reviews·Josephine M Forbes, Mark E Cooper
Oct 30, 2016·The Biochemical Journal·Santosh Kumar GoruAnil Bhanudas Gaikwad
Jun 25, 2019·Frontiers in Genetics·Harvest F Gu
Dec 16, 2019·Archives of Pharmacal Research·Jeena GuptaDhiraj Kabra
Dec 29, 2019·Nutrients·Danja J Den HartoghEvangelia Tsiani
Dec 15, 2017·International Journal of Molecular Sciences·Stefania BelliniGabriella Gruden
Nov 28, 2012·Diabetes/metabolism Research and Reviews·Mary Ngoc DangPaolo Pozzilli
Jun 13, 2020·International Journal of Molecular Sciences·Julio M Martinez-MorenoAna B Sanz
May 22, 2020·Frontiers in Cardiovascular Medicine·Wawaimuli ArozalVivian Soetikno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.