Change in prostate cancer grade over time in men followed expectantly for stage T1c disease.

The Journal of Urology
Todd B SheridanJonathan I Epstein

Abstract

We assessed whether the Gleason grade changes in men followed expectantly with nonpalpable prostate cancer diagnosed on needle biopsy (stage T1c). We studied 241 men with stage T1c prostate cancer who were treated expectantly with repeat yearly needle biopsy sampling to assess for cancer progression. Following the initial cancer diagnosis all men had at least 1 other biopsy demonstrating cancer. Median patient age was 66 years. The number of biopsies showing cancer over time was 2 in 119 (49.4%), 3 in 74 (30.7%), 4 in 33 (13.7%) and 5 or greater in 15 (6.2%). The average followup for those without progression was 32.3 months. Of 241 cases 45 (18.7%) showed a significant change in grade from Gleason score 6 or less to Gleason score 7 or greater (Gleason score 7 in 41 cases, Gleason score 8 in 4 cases). Of 45 (53.5%) cases 24 that showed progression did so within 24 months of diagnosis. Within the first 3 years after diagnosis of Gleason score 6 prostate cancer, there is a relatively low risk of grade progression. Within the first 3 years, our data suggest that in most cases tumor grade did not evolve but rather that the higher grade component was not initially sampled since most grade changes occurred relatively soon after biops...Continue Reading

References

Sep 4, 1991·Journal of the National Cancer Institute·A S WhittemoreR Betensky
Jan 1, 1989·British Journal of Cancer·P N Brawn, V O Speights
Jul 15, 1983·Cancer·P N Brawn
Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Jun 1, 1997·The Journal of Urology·H B CarterJ I Epstein
May 1, 1997·The American Journal of Surgical Pathology·D M SteinbergJ I Epstein
Feb 14, 1998·Journal of the National Cancer Institute·L ChengZ Zhuang
Jul 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lawrence TruePeter S Nelson
Jul 22, 2006·International Journal of Cancer. Journal International Du Cancer·Gerrit DraismaHarry J de Koning
Dec 19, 2006·Nature Genetics·Scott A TomlinsArul M Chinnaiyan

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Citations

Nov 1, 2011·QJM : Monthly Journal of the Association of Physicians·M R Goldstein, L Mascitelli
Dec 4, 2012·Cancer Research·Adam G SowalskySteven P Balk
Oct 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H Ballentine CarterJonathan I Epstein
Nov 23, 2013·AJR. American Journal of Roentgenology·Gillian MurphyBoraiah Sreeharsha
Apr 30, 2013·The Journal of Urology·Marc Dall'Era
Dec 19, 2012·The Journal of Urology·Scott E EggenerBertrand Guillonneau
Oct 25, 2012·European Urology·Fadi BrimoJonathan I Epstein
Aug 21, 2012·The Journal of Urology·Jeffrey J TosoianLori J Sokoll
Jan 19, 2016·Prostate International·Selahattin ÇalışkanMuhammet Karaman
Feb 24, 2009·The Journal of Urology·Scott E EggenerBertrand Guillonneau
Nov 15, 2011·BJU International·H Ballentine Carter
Nov 28, 2015·Surgical Pathology Clinics·Adebowale J Adeniran, Peter A Humphrey
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paras B SinghMark Emberton
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sima P PortenPeter R Carroll
May 14, 2017·World Journal of Urology·Fanny SampurnoSue Evans
Jan 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam G SowalskySteven P Balk
Aug 16, 2013·Cancer Research·Kathryn L PenneyMichelangelo Fiorentino
Dec 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ganesh S PalapattuLeonard S Marks
Feb 29, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Alessandro CaputoPio Zeppa

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